Flashcards in Risk of inherited disease Deck (14):
the relative ability of organisms to survive (long enough) too pass on their genes
Alleles can affect fitness
deleterious allele (decrease fitness)
advantageous allele (increase fitness)
Mutations in recessive genes rarely affect...
Notable recessive diseases
sickle cell disease
Mutation in dominant and X-linked genes can be...
inherited OR de novo
up to a third of lethal X-linked cases are due to...
de novo mutations
allele frequencies remain constant throughout generations
Non-random mating can
increase mutant alleles
random fluctuation of one allele transmitted to high proportion of offspring by chance
choosing of partners who share characteristics (deafness etc)
marriage between close blood relatives
the frequency with which a trait is manifested by individuals carrying the gene
2 maternal genomes