Antimicrobial Protein Flashcards

(79 cards)

0
Q

Example of antimicrobial protein

A

Lysozyme

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1
Q

Proteins that attack microbes or stall reproduction of microbes.

A

Antimocrobial protein

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2
Q

Secreted by virus-infected cells; prevent cell to cell spread.

A

Interferons

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3
Q

Not virus specific

A

Interferons

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4
Q

Neighboring cells are stimulated to produce chemicals that can inhibit viral infection

A

Interferons

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5
Q

A specific type that activated phagocytes; activate macrophage

A

Interferons

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6
Q

Secreted by macrophages

A

Defensins

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7
Q

Third line of defense. There is lag time between exposure and maximal response. Not genetically determined. Affords protection against re-exposure to the same pathogen.

A

Adaptive/Acquired immunity/Specific defense mechanism

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8
Q

Responsible in the defense mechanism. Found in the blood and lymph.

A

Lymphocytes

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9
Q

Activated by cytokines from phagocytes.

Display specificity to epitopes on antigens. Have specific membrane-bound antigen-receptors.

A

Lymphocytes

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10
Q

Two types of lymphocytes.

A

B- cells

T-cells

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11
Q

Mature in marrow

A

B-cells

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12
Q

Mature in thymus.

A.k.a helper/cytotoxic/killer/suppressor/memmory

A

T-cells

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13
Q

Requires some time to react to an invading organism

A

Adaptive

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14
Q

Present and ready to mobilized upon infection

A

Innate

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15
Q

Antigen specific and reacts only with the org that induced the response.

A

Adaptive

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16
Q

Not antigen specific and reacts equally to a variety of organism

A

Innate

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17
Q

Does not demonstrate immunological memoryo

A

Innate

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18
Q

Demonstrates immunological memory

A

Adaptive

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19
Q

Develops upon the exposure to antigen
Through antigen
Obtained in the course of daily life

A

Naturally Acquired Active Immunity

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20
Q

Occurs through vaccination

A

Artificially Acquired Active Immunity

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21
Q

Type of Acquired/Adaptive Immunity that has natural antibodies. No immune response to antigen.

A

Naturally Acquired Passive Immunity

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22
Q

Type of Acquired/Adaptive immunity: injection of antibodies

A

Artificially Acquired Passive Immunity

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23
Q

Adaptive Immunity can be?

A

Cellular (cell-mediated) and Humoral (antibody-mediated)?

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24
Involves B cell activation; production of antibodies in blood plasma and lymph.
Humoral immunity
25
Involves immunoglobulin production by B lymphocytes; complement can be considered
Humoral Immunity
26
Humoral immunity: | Antibodies are produced by?
Lymphocytes; specifically B cells
27
Humoral immunity: | Antibodies are found where?
ECF and surface of B cells
28
Programmed cell death (Falling away)
Apoptosis
29
Many virus infected cell will undergo this to help prevent spread of the infection
Apoptosis
30
Humoral immunity occurs in 3 phases: accomplished by phagocytosis
Antigen elimination
31
Humoral immunity occurs in 3 phases: | After exposure to Ag. IgM is the first to appear.
The primary response
32
Humoral immunity occurs in 3 phases: second or subsequent exposure to the same antigen elicits secondary response. IgG is the predominant.
The secondary response
33
Active against cancer cells; class I mhc. Occurs when antigen displayed by antigen presenting cells activated cytotoxic T cell. Cytotoxic cell can differentiate to memory cells or active cytotoxic t cells.
Cellular Immunity
34
Transplanted tissue. Important in viral and fungal infections and in infections. Involved specialized set of lymphocytes called T cells that recognize foreign antigens in the surface on cells, org or tissues.
Cellular mediated immunity
35
These cells play a role in cell-mediated immunity.
Macrophages, Cytotoxic t cells, Natural Killer cells
36
Chemical messengers of immune cells
Cytokines
37
Communication bet WBCs.
Interleukins
38
Protect against viral infections
Interferons
39
Attract WBCs to infected areas
Chemokines
40
Found on all cells
MHC Class I
41
Found in phagoctyes
MHC Class Ii
42
Inoculation of smallpox
Variolation
43
Inoculation of cowpox
Vaccination
44
When most of population is immune to a disease
Herd immunity
45
Types of vaccines: | It contains weakened microbes that multiply at only low levels, inducing a strong immune response
Live, attenuated vaccines
46
Types of vaccines: | Contain killed pathogens, which induce a weaker immune response.
Inactivated vaccines
47
Types of vaccines: | Contain only those parts of the antigens that stimulate a strong immune response.
Subunit vaccine
48
Types of vaccine that depend on the ability of some cells to: take up and translate foreign DNA. And display the resulting proteins, inducing a strong immune response.
DNA Vaccines
49
Increase efficacy of a vaccine or toxoid by increasing availability of the antigen in the lymphatic system.
Adjuvants
50
Principle Bacterial Vaccines: purified polysaccharide from N.menigitidis
Meningococcal meningitis
51
Principle Bacterial Vaccines: polysaccharides conjugated with protein.
Haemophilus influenza type B meningitis
52
Principle Bacterial Vaccines: S.pneumonia antigens conjugated with protein
Pneumococcal conjugate vaccine
53
Principal Virus Vaccines: live vaccinia virus
Smallpox
54
Principle virus vaccines: inactivated virus
Poliomyletis; Rabies; Hepa A
55
Principle Virus Vaccines: inactivated or attenuated (nasal) virus
Influenza
56
Principle virus vaccine: attenuated virus
Measles, Mumps, Rubella, Chickenpox
57
Principle virus vaccines: antigenic fragments
Hepa B
58
Content: live, weakened bacteria/virus
Attenuated
59
Killer virus/bacteria
Killed
60
Detoxified toxin
Toxoid
61
Aging of cultures; culture on high temp; passage through another host sp; drying.
Attenuated
62
Heat chemicals (HCHO, phenol and alcohol) Uv radiation/photodynamic inhibition.
Killed
63
Detoxified by adding 0.4% HCHO
Toxoid
64
Long lasting
Attenuated
65
Shorter
Killed
66
Longer and permanent
Toxoid
67
More potent
Attenuated
68
Less potent
Killed
69
Strong
Toxoid
70
Lyophilized form
Attenuated
71
Presented in antiseptics like phenol, merthiolate and alcohol
Killed
72
Fluid forms are precipitated by an alum/Al(OH)3
Toxoid
73
TB, yellow fever, smallpox and polio
Attenuated
74
Whooping cough, typhoid fever, cholera, plague, rabies
Killed
75
Diphtheria, tetanus
Toxoid
76
2 kinds of granules which are involved in antimicrobial properties
Azurophilic granule | Specific granule
77
The process of white blood cells migrating outside of blood vessels. Often caused by trauma.
Diapedesis
78
Cells that are primarily involved in Diapedesis
Neutrophils and cytokines