Antimycobacterial and Antifungal Agents Flashcards
(15 cards)
What are mycobacteria?
a. A genus of bacteria
b. A genus of fungi
c. A type of viruses
a. A genus of bacteria
What is a structural difference in mycobacteria that can be exploited for selective targeting?
a. The composition of the cell membrane
b. The composition of the cell wall
c. The lipoproteins on the cell membrane
b. The composition of the cell wall
Which mycobacterial disease has a first and a second line treatment?
a. Leprosy
b. Tuberculosis
b. Tuberculosis
What is the mechanism of action of isoniazide?
a. The proposed mechanism of action is the interference with the synthesis of mycolic acids
b. The proposed mechanism of action is the inhibition of folic acid synthesis
c. The proposed mechanism of action is the promotion of oxidative stress
d. The proposed mechanism of action is the inhibition of protein synthesis
a. The proposed mechanism of action is the interference with the synthesis of mycolic acids
The aminoglycoside agents streptomycin and kanamycin are used as antimycobacterial. Is this correct?
a. Yes
b. No
a. Yes
Dapsone and p-aminosalicylic acid are two antimycobacterial agents to treat dapsone and tuberculosis, respectively. They are antimetabolites that interfere with the synthesis of folate. Which other class of antibacterial agents have the same mechanism of action?
a. Macrolides
b. Quinolones
c. Beta lactams
d. Tetracyclines
e. Sulfonamides
e. Sulfonamides
Which is the agent used both as an antibacterial and as an antimycobacterial that interferes with the cell wall synthesis?
a. Penicillin V
b. Vancomycin
c. Cycloserine
d. Bacitracin
c. Cycloserine
Which of the following statements is incorrect?
a. Fungi are eukaryotes
b. Fungal infection can affect different parts of the body
c. All fungi are pathogenic
d. Fungi have a cell wall
c. All fungi are pathogenic
What is the mechanism of action of triazole antifungal agents?
a. They interfere with the duplication of DNA in fungi
b. They inhibit ergosterol synthesis and impair the functionality of cell wall
c. They inhibit protein synthesis in the fungal cell
You Answered
d. They inhibit ergosterol synthesis and impair the functionality of cell membrane
b. They inhibit ergosterol synthesis and impair the functionality of cell wall
Which statement amongst the following is incorrect?
a. Protozoa have two reproductive cycles
b. Protozoa are eukaryotes
c. Malaria is not a protozoal disease
d. Amebiasis and leishmaniasis are protozoal diseases
c. Malaria is not a protozoal disease
he molecule below is sodium stibogluconate. It is used against a protozoal disease. Which one of the following?
a. Amebiasis
b. No answer text provided.
c. Giardiasis
d. Trypanosomiasis
e. Leishmaniosis
b. No answer text provided.
The molecule below is pentamidine. It is used against a protozoal disease. Which one of the following?
a. Trypanosomiasis
b. Leishmaniosis
c. Amebiasis
d. Giardiasis
b. Leishmaniosis
Metronidazole is the molecule with the structure below. It is an antiprotozoal agent but it is used as an antibacterial too.
What is the mechanism of action of this agent?
a. It blocks the synthesis of the cell wall
b. It blocks the synthesis of DNA
c. It impairs the functionality of the membrane
d. It causes oxidative stress in the microbial cell
d. It causes oxidative stress in the microbial cell
What is the genus of the aetiological agent that causes malaria?
a. Trypanosoma
b. Plasmodium
c. Amoeba
d. Trichomonas
b. Plasmodium
Quinolines are a class of antimalarials. Which of the statements below about quinolines is incorrect?
a. Quinine is the natural product that inspired the synthesis of the quinoline series
b. Quinolines are used both for the prophylaxis and the treatment of malaria
c. Quinolines act against the erythrocytic phase of the parasite
d. Quinolines prevent the storage of haem as hemozoin biocrystals
e. Quinolines do not easily induce resistance in the plasmodium
e. Quinolines do not easily induce resistance in the plasmodium
