Antiplatelet And Anticoagulant

Question 1

Thromboxane synthesis inhibitor (Antiplatelet)

Answer 1

Acetylsalicylic acid

Question 2

GP 2b3a receptor antagonist (antiplatelet)

Answer 2

Tirofiban

Question 3

ADP receptor antagonist (antiplatelet)

Answer 3

Clopidogrel and ticagrelor

Question 4

Antiplatelets are

Answer 4

Thromboxane synthesis inhibitor,GP 2b3a receptor antagonist and ADP receptor antagonist

Question 5

Thromboxane synthesis inhibitor or Aspirin inhibits the enzyme

Answer 5

COX 1

Question 6

GP 2b3a receptor are needed for

Answer 6

Platelets aggregation

Question 7

ADP induce upregulation of

Answer 7

GP 2b3a receptor

Question 8

Final stage of platelets aggregation

Answer 8

Fibrinogen binding to receptor

Question 9

Use of thromboxane synthesis inhibitor

Answer 9

Secondary cerebrovascular and cardiovascular thrombosis prevention and ACS

Question 10

Side E of Aspirin

Answer 10

Bleeding from GIT

Question 11

GP 2b3a receptor antagonist use

Answer 11

ACS

Question 12

ADP receptor also known as

Answer 12

P2Y12 receptors

Question 13

Clopidogrel is a prodrug that should be activated by

Answer 13

CYP450 and does irreversible inhibition throughout life of PLT

Question 14

Ticagrelor does

Answer 14

Reversible inhibition of P2Y12 receptor and also indirectly inhibit Gp2b3a receptor

Question 15

Clinical use of ADP receptor antagonist

Answer 15

2 prevention of cerebrovascular and cardiovascular y and dual antiplatelet therapy for ACS and post ACS

Question 16

In using Ticagrelor, PLT restore fn in

Answer 16

36 to 48 hr

Question 17

Risk of bleeding in antiplatelet agents increase with

Answer 17

NSAIDS and GC

Question 18

In case of aspirin intolerance —— is used

Answer 18

Clopidogrel

Question 19

Non selective indirect coagulation factor inhibitor

Answer 19

Heparin(HMW), Enoxaparin (LMW)

Question 20

Selective indirect inhibitors of factor 10a

Answer 20

Fondaparinux

Question 21

Selective direct inhibitor of factor 2a

Answer 21

Dabigatran

Question 22

Selective direct inhibitor of factor 10a

Answer 22

Rivaroxaban and apixaban

Question 23

Zymogen synthesis inhibitor or vit K antagonist

Answer 23

Warfarin

Question 24

Ischemic heart disease treatment

Answer 24

Anti Ischemic therapy,anti platelets agents and lipid correcting agents

Question 25

Acute Coronary syndrome treatment

Answer 25

Nitrate, oxygen therapy, analgesia and antiplatelet therapy

Question 26

In case of DVT,INR is

Answer 26

2 to 3

Question 27

INR is

Answer 27

Patients clotting time to mean normalized clotting time

Question 28

Antithrombin 3 is a

Answer 28

Physiological Inactivator of serum proteases synthesized in liver

Question 29

To treat Afib

Answer 29

Anticoagulant can be used

Question 30

INR monitoring is required for

Answer 30

Vit K antagonist therapy

Question 31

Complications of anticoagulant therapy are

Answer 31

Uncontrolled bleeding

Question 32

Treatment with selective factor 10 a and 2a should be discontinued

Answer 32

24 to 48hr before surgery

Question 33

Vit K antagonist therapy should be discontinued

Answer 33

1 to 5 days before surgery (depends on INR)

Question 34

Antidote of heparin

Answer 34

Protamine sulphate

Question 35

SE of heparin

Answer 35

Hemorrhage and heparin induced Thrombocytopenia

Question 36

Heparin use

Answer 36

DVT prevention and therapy and ACS

Question 37

Heparin toxicity can cause severe bleeding from

Answer 37

Abdominal walls, subcutaneously,spinal hematoma, intracranial bleeding

Question 38

Heparin inhibition ratio

Answer 38

1:1

Question 39

Enoxaparin inhibition ratio

Answer 39

2:1 to 4:1 mainly inhibits factor 10 than 2

Question 40

Rivaroxaban use

Answer 40

DVT and PE treatment and prevention,stroke prevention (Afib)

Question 41

Rivaroxaban antidote

Answer 41

Andexanet alpha

Question 42

Dabigatran antidote

Answer 42

Idarucizumab

Question 43

Warfarin

Answer 43

Vit K epoxide reductase inhibition (inhibition of vit K conversion)inhibition of synthesis of 2,7,,9,10 factors ,inhibition of protein c and s

Question 44

Therapeutic effect of warfarin reach at day

Answer 44

5

Question 45

Vit K is required for

Answer 45

Glutamic acid carboxylation reaction

Question 46

Max effect of warfarin reached on ---days

Answer 46

2to 3 daya

Question 47

T1/2 of warfarin

Answer 47

35 hrs

Question 48

Warfarin toxicity

Answer 48

Teratogenic, ecchymoses, subconjunctival hemorrhage, gingival bleeding, internal organ bleeding like GIT, intracranial bleeding

Question 49

Warfarin toxicity treatment

Answer 49

PCC (prothrombin complex concentrate), FFP iv and phytamenadione ( vitk) iv/po

Question 50

Thrombolytic/fibrinolytic agents

Answer 50

Alteplase

Question 51

Overdose of alteplase cause

Answer 51

Intracranial hemorrhage

Question 52

Use of alteplase

Answer 52

ACS, pulmonary embolism, ischemic stroke therapy

Question 53

Alteplase and streptokinase promotes the conversation of plasminogen to plasmin while ------+inhibits ot

Answer 53

Tranexamic acid (antifibronolytic)

Question 54

Antihemorrhagic or hemostatic agents are

Answer 54

Fibrinolysis inhibitor (tranexamic acid) and vasopressin receptor agonist (desmopressin)

Question 55

Hemophilia A

Answer 55

Inherited decreased factor 8

Question 56

Von willebrands disease

Answer 56

Mucosal-skin hemorrhage

Question 57

Von willebrands factor

Answer 57

Plasma glycoprotein involved in both primary hemostasis and coagulation process,acts as factor 8 transporter.So imp role in platelets adhesion and thrombus formation process

Question 58

Tranexamic acid (reversible lysine analogue) use

Answer 58

Complications of fibrinolytic (thrombolytic therapy or hyperfibrinolysis;massive bleeding or it's prognosis

Question 59

Tranexamic acid SE

Answer 59

Seizures at high dose

Question 60

Tranexamic acid interactions with oral contraceptive cause risk of

Answer 60

Thrombosis

Question 61

Desmopressin (vasopressin analogue)V2 receptor agonists

Answer 61

Increase factor 8 and Von willebrands factor and increase platelets adhesion in arterial and venous endotheo

Question 62

Use of desmopressin

Answer 62

Scheduled surgery in patients with hemophilia a and Von willebrands disease; bleeding control in patients with prolonged blood flow time