antiplatelets

Question 1

ADP Inhibitor(irreversible)

Answer 1

Clopidogrel(PRODRUG), ticlopidine, prasugrel

AA: bleeding, neutropenia, TTP, itch. INT: PPIs reduce effectiveness.

Question 2

ADP Inhibitor (reversible)

Answer 2

Ticagrelor: reversible inhibitor, better for acute situations.

Question 3

Glycoprotein IIB/IIA Inhibitor

Answer 3

Abciximab:
Eptifibatide
Tirofiban

Question 4

Abciximab:

Answer 4

irreversible. Fab fragment against IIB/IIIA.

Question 5

Eptifibatide:

Answer 5

reversible, binds to fibrinogen site specifically, shorter duration.

Question 6

Tirofiban:

Answer 6

shorter duration, reversible.

Question 7

Phosphodiesterase-3 Inhibitors:

Answer 7

increase levels of cAMP, inhibiting aggregation of platelets. Reversible inhibitors of PDE-3. Not as strong of ADP inhibitors. Can maybe also increase adenosine levels which helps with the aggregation shit. VASORELAXATION AT HIGH DOSES.
Cilostazol, dipyridamole: cilo can have dd interactions, dipyri is pH dependent.