Antiplatelets, Anticoagulants, and Thrombolytics

Question 1

Aspirin

Answer 1

Irreversibly inhibits COX-1

Question 2

Dipyridamole, Cilostazol

Answer 2

Phosphodiesterase inhibitors, promote vasodilation and block platelet aggregation

Question 3

Ticlodipine

Answer 3

ADP antagonist

Question 4

Clopidogrel, Ticagrelor

Answer 4

P2Y12 ADP receptor antagonists

Question 5

Abciximab and Eptifibatide

Answer 5

Block fibrinogen binding to Glycoprotein IIb/IIIa on platelets

Question 6

Heparin

Answer 6

Binds antithrombin III which inhibits thrombin and factor Xa

Unfractionated blocks both
LMWH and Fondaparinux block Xa preferentially

Question 7

Protamine sulfate

Answer 7

Antagonist for unfractionated heparin and LMWH to a lesser extent

Question 8

Hirudin, Desirudin, Bivalirudin, Argatrobin, Dabigatran

Answer 8

Direct thrombin inhibitors

Question 9

Warfarin

Answer 9

Inhibits VKORC1 (enzyme responsible for activating vitamin K)

Question 10

Apixaban, Rivaroxaban

Answer 10

Direct factor Xa inhibitors

Question 11

Alteplase, Reteplase, Terecteplase

Answer 11

Recombinant tPA (activates plasmin which breaks down fibrin)

Question 12

Aminocaproic acid, Tranexamic acid

Answer 12

Antidotes of tPA