Flashcards in Antipsychotics: Lacher Deck (15):
What do Schizophrenic brains produce more of than normal brains?
How do first generation antipsychotics work?
Block D2 receptors in all 4 dopaminergic pathways
Name some first generation antipsychotics.
Name the 4 dopaminergic pathways and where they come from and go to.
1. Mesolimbic: ventral tegmentum to the nucleus accumbens.
2. Mesocortical: ventral tegmentum to frontal and limbic cortex.
3. Nigrostriatal: Substantia nigra to stratum.
4. Tuberoinfundibular: Hypothalamus to anterior pituitary
Which dopaminic pathway is responsible for mediating the positive symptoms of Schizophrenia?
Which dopaminergic pathway mediates the negative symptoms of Schizophrenia?
Which dopaminergic pathway mediates posture and voluntary movement (blocking it may lead to the Parkinsonian symptoms of Schizophrenia)?
Which dopaminergic pathway inhibits prolactin release?(blocking it may result in Galactorrhea/Amenorrhea)
How do second generation antipsychotics work?
Block D2 an 5-HT2A receptors (blocking 5-HT2A receptors actually leads to an increase in dopamine release).
If you use a second generation antipsychotic, what might it do to negative symptoms?
It may improve them!
2nd generation antipsychotic. Reduction in suicide! No Parkinson-life side effects.
Life-threatening adverse effect: Agranulocytosis.
Name the second generation antipsychotics that do not induce agranulocytosis (but the aren't as good as Clozapine in terms of no Parkinsonian symptoms and reduction of suicide).
Risperidone (most potent), Olanzapine, Quetiapine, Ziprasidone, Aripiprazole
What are the three classes of symptoms in Schizophrenia?
Positive symptoms (ex. hallucinations), negative symptoms (Ex. social isolation), and cognitive symptoms (poor concentration, slow thinking)
What can cause tradeoff dyskinesia?
DA receptor disuse supersensitivity (take patient off of antipsychotic and the D2 receptors become really sensitive to dopamine!
More common in First Gen's.