Flashcards in Stimulants: Lichtblau Deck (21):
How do amphetamines and methylphenidate work as you increase dose?
1. Increase release of NE and DA
2. Block NE and DA re-uptake
3. Inhibit Monoamine Oxidase (MAO)
How does Cocaine work?
Blocks repute of NE (motor) and DA (euphoria)
Describe the tolerance to Cocaine.
There is some, but they can take the same dose every day and get the same effect
MDMA enters the brain easily, why?
What is the mechanism of action of MDMA?
Stimulates release of and inhibits the repute of NE, DA, Epinephrine, and 5-HT.
Which drug is an empathogen?
Which NT is released in response to Ecstasy and can cause a person to get to dangerously high temperatures?
What are the sympathomimetics in bath salts?
Methylenedioxypyrovalerone and Mephedrone
Name the two xanthines
Theophylline and caffeine
What is Theophylline generally used for?
Tx and prophylaxis of bronchial asthma (smooth muscle relaxant) and is Analeptic: increases respiration
Why is caffeine used in migraine medications?
because it increases cerebral vascular resistance...we want vasoconstriction for migraine tx.
What drug is discouraged for use in children because of sever skin rashes?
Name the Eugenic drugs (wakefulness enhancers) that are used for tx of narcolepsy, shift work disorder, and excessive daytime sleepiness.
Modafinil and Armodafinil
How do Modafinil and Armodafinil work?
They increase NE and DA release and elevate hypothalamic histamine levels. (and increase 5-HT release?)...seems unknown
Which drugs have lower abuse potential?
What do sympathomimetics do for speed and accuracy?
Increase speed, not accuracy
When do sympathomimetics exert their greatest effects?
When you are fatigued or have lack of sleep
What do sympathomimetics do to BP?
Describe sympathomimetic toxicity.
Acute: "Exaggerated therapeutic effects", Chronic: "Amphetamine psychosis"--> hallucinations, paranoid delusions, marked weight loss
How do you treat sympathomimetic toxicity?
Antipsychotic drug and acidify urine to ionize the drug