Antispasmodics Flashcards
(8 cards)
What is the main use of antispasmodic drugs?
To relieve gastrointestinal (GI) smooth muscle spasms.
What is the mechanism of action of antimuscarinic antispasmodics?
They reduce intestinal motility by blocking muscarinic receptors.
Why do tertiary amines have a higher risk of CNS side effects? - Atropine sulfate and Dicycloverine hydrochloride.
Because they are more lipid-soluble and can cross the blood–brain barrier.
What is a limitation of quaternary ammonium compounds?
They have poorer absorption from the GI tract.
What is notable about hyoscine butylbromide?
It is GI-specific but poorly absorbed.
Name three direct-acting smooth muscle relaxants used for GI spasm.
Alverine citrate, Mebeverine hydrochloride, and Peppermint oil.
How do direct-acting smooth muscle relaxants work?
They act directly on intestinal smooth muscle to relieve spasm.
What condition are direct-acting smooth muscle relaxants particularly used for?
Irritable Bowel Syndrome (IBS).
