ANTITUBERCULAR DRUGS

Question 1

First-line drugs

Answer 1

isoniazid
rifampicin
pyrazinamide
ethambutol
streptomycin

Question 2

Second-line drugs

Answer 2

-Fluroquinolones( ofloxacin, levofloxacin, moxifloxacin,
ciprofloxacin)
✓ Clarithromycin
✓ Amikacin
✓ Capreomycin
✓Para-aminosalicyclic acid
✓ Cycloserine
✓ Ethionamide

Question 3

Intensive phase

Answer 3

INH (H) 300 mg + Rifampin (R) 600 mg +
Pyrazinamide (Z) 1500 mg + Ethambutol (E) 1000 mg
OR

Streptomycin (S) 1000 mg + Pyridoxine 10 mg

daily for 2 months or thrice weekly period 2 months

Question 4

Continuation phase-

Answer 4

INH (H) 300 mg + Rifampin (R) 600 mg + Pyridoxine 10 mg daily for 4 months

Question 5

INH:

Answer 5

potent bactericidal

Question 6

Rifampin:

Answer 6

potent bactericidal

Question 7

Pyrazinamide

Answer 7

Weak bactericidal, active against
intracellular bacilli

Question 8

Ethambutol

Answer 8

bacteriostatic, prevents resistance development

Question 9

Streptomycin

Answer 9

bactericidal, active against extracellular rapid growers.