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Flashcards in Antitumor Antibiotics Deck (1)
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Prototype Drugs: Doxorubicin (Adriamycin)

•Therapeutic classification
–Antineoplastic
•Pharmacologic classification
–Antitumor antibiotic, anthracycline
•Pregnancy category D

•Contraindications
–Pregnancy
–Lactation
–Myelosuppression
–Thrombocytopenia
-Preexisting cardiac disease
–Obstructive jaundice
–Previous treatment with complete cumulative doses of doxorubicin or daunorubicin

•Adverse effects
–Turns urine and tears a red color
–Temporary decreased fertility
–Secondary malignancies
–Nausea
–Vomiting
–Rash
–Mucositis
–Excessive lacrimation

•Patient/family teaching
–Expect complete loss of hair (reversible), which may also involve eyelashes and eyebrows, beard and mustache, and pubic and axillary hair
–Expect urine to become red for 1 to 2 days after administration