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Flashcards in Antimetabolites Deck (1)
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Prototype Drug: Methotrexate (MTX, Rheumatrex, Trexall)

•Therapeutic classification
–Antineoplastic
•Pharmacologic classification
–Antimetabolite, folic acid analog, immunosuppressant, disease-modifying antirheumatic drug (DMARD)
•Pregnancy category X

•Contraindications
–Thrombocytopenia
–Anemia
–Leukopenia
–Concurrent administration of hepatotoxic drugs and hematopoietic suppressants
–Alcoholism
–Lactation

•Adverse effects
–Nausea
–Vomiting

•Patient/family teaching
–Avoid alcohol
–Practice fastidious mouth care
–Avoid exposure to sunlight and ultraviolet light
–Do not self-medicate with vitamins
-Avoid echinacea
–Limit intake of caffeine
–Use contraceptive measures during and for at least 8 weeks following therapy