Antiviral agents Flashcards Preview

Clinical Pathology G > Antiviral agents > Flashcards

Flashcards in Antiviral agents Deck (26):
1

Name some acute viral infections

Influenza, measles, mumps, Hepatitis A

2

Name some chronic latent viral infections

herpes simplex, cytomegalovirus

3

Name some persistent chronic viral infections

HIV, hepatitis B, hepatitis C

4

What are the 3 main components of viruses?

Nucleic acid (DNA or RNA)
Protein (coat - structural, enzymes-non-structural)
+/- Lipid envelope

5

How does a virus replicate?

1. Virus attachment to cell (via receptor)
2. Cell Entry
3. Virus Uncoating
4. Early proteins produced – viral enzymes
5. Replication
6. Late transcription/translation – viral structural proteins
7. Virus assembly
8. Virus release

6

What does AZT stand for?

azidothymidine

7

What is AZT?

It is a Nucleoside Reverse Transcriptase Inhibitor (NRTI)

8

What are the 2 categories of NRTIs?

Pyrimidine analogues

Purine analogues

9

Name 2 purine analogue NRTIs

abacavir
tenofovir

10

Name a thymidine analogie NRTI

Zidovudine

11

Name a cytosine analogue NRTI

Lamivudine

12

What is HBV?

the Hepatitis B virus

13

Which NRTIs also act against HBV?

Lamividine
Tenofovir

14

What is a NNRTI?

Non-nucleotide reverse transcription inhibitor

15

Give 2 examples of NNRTIs

Efavirenz
Nevirapine

16

What does PI stand for?

Protease inhibitor

17

What are some PIs?

Atazanavir
Darunavir
Fospamprenavir
Lopinavir
Nelfinavir
Ritonavir*
Saquinavir

18

Give 3 types of newer HIV drugs

Fusion inhibitor

Integrase Inhibitors

Chemokine receptor antagonists

19

Name an example of a fusion inhibitor

Enfuviritide

20

Name an example of an integrase inhibitor

Raltegravir

21

Name an example of a chemokine receptor antagonist

Maraviroc

22

What does HAART stand for?

Highly Active Antiretroviral Therapy

23

What does HAART consist oF?

2 NRTIs + NNRTI
2 NRTIs + boosted PI

24

When is HAART started?

When CD4 falls

25

What is the aim of HAART?

to switch off virus replication

26

What are 5 important common antivirals?

Aciclovir

Ganciclovir

Cytomegalovirus (CMV)

Oseltamivir and Zanamavir

Ribavirin

Interferons