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Flashcards in Antiviral Drugs Deck (76)
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1

Antivirals are generally 

virostatic

2

Cross resistance example given with TK mutation

Idoxuridine and acyclovir

3

Three categories of agents that prevent entry

Attachment inhibitors

Coreceptor antagonists

Fusion inhibitors

4

Maraviroc MOA

CCR5 coreceptor antagonist

5

HIV1 can resist maraviroc by 

using drug-bound form of CCR5

This is called nonompetitive resistance 

6

Cenicriviroc MOA

dual CCR5 and CCR2 antagonist

7

Enfuvirtide MOA

inhibits gp41

 

(derived from natural gp41 HR2 sequence)

**does NOT have good oral BA

8

Inhibition of uncoating at the level of the endosomme/lysosome may be a good target because it...

takes place at a specific pH (low)

9

Arildone MOA

inhibits picornavirus uncoating

 

*inserts into a canyon in the VP1 viral protein and blocks ion transport

10

Plecoranil MOA

stops shedding of nucleocapsid proteins from RNA

11

First integrase inhibitor

Raltegravir

12

Second generation integrase strand transfer inhibitor (INSTI)

Dolutegravir

 

has a limited cross-resistance profile

13

Best class of AV drugs

Ones that act on replication of the genome

14

Because thymidine kinase is _____, nucleoside analogs can be administered in _______ form.

This provides what sort of advantage?

Viral TK is less specific

administered in unphosphorylated form

 

*Un-P drug enters cells more easily than phosphorylated ones

15

Nucleoside analog drugs generally cause ____

chain termination

16

Examples of nucleoside analogs

Idoxuridine

Ribavirin

Acyclovir/Gancyclovir

Azidothimidine

17

Two drugs that can interfere with mRNA transcription processing

Ribavirin

Interferon

18

Drugs that target proein translation

no specific inhibitors!

 

Interferon is non-specific for this

19

Post-trans modifications that can be targetss

glycosylation

phosphorylation

myristoylation

sialidation

20

Neuraminidase inhibitor drugs

Zanamavir

Oseltamavir

21

Neuraminidase function

"sialidase" = removes sialic acid from surface at level of glyccoproteins and glycolipids

 

22

Zanamavir MOA

inhibits NA of influenza A + B

23

Zanamavir requires

aersosol delivery

24

Oseltamavir is an analog of 

carbocyclic sialic acid

25

Other drug related to NA inhibitors

laninamivir

26

What is nirazoxamide?

a thiazolide

it might block glycosylation of viral hemagglutinin in the Golgi

27

Nitazoxanide is effective against

Yes

28

Protease inhibitors are all ____

 

Examples?

substrate analogs

 

Aquinavir, ritonavir, indinavir, lopinavir, tipranavir, darunavir

 

29

Protease inhibitors for HCV

Boceprevir and Telprevir

30

Amantadine is ___

lysosomotropic