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Flashcards in APH Axis Deck (11):
0

Fludrocortisone

Glucocorticoid & mineralocorticoid
Similar actions to Aldosterone,
Combine w/ a glucocorticoid for replacement tx in adrenocortical insufficiency (de Na+, dehydration, inc K+, arrhythmias)

1

Hydrocortisone

Cortisol
Mineralocorticoid & glucocorticoid (1:1)
Weak anti-inflammatory, glucocorticoid replacement (adrenal insuff)

2

Cortisone

Mineralocorticoid, glucocorticoid
First converted to hydrocortisone in liver (so less potent)

3

Prednisone
Prednisolone

Glucocorticoid > mineralocorticoid
Prednisone first converted to prednisolone by liver to be active

4

TRiamcinolone
Methylprednisolone

Glucocorticoid (no mineralocorticoid activity
Anti-inflammatory only

5

Dexamethasone

Glucocorticoid (high potency)- Antiinflammatory
For cerebral edema (x CNS)
Used to measure endogenous cortisol levels (no x-rxn)
Joint injection in RA

6

Fluticasone

Glucocorticoid, inhaled/intranasal use
Inhaled- DOC for asthma (+long acting B-agonist: salmeterol)

7

Aminoglutethimide

Cytadren -Off market
Inhibits cholesterol-> pregnenolone, so inhibits all steroid synth
For cushings, breast and prostate Ca (that doesn't respond to tamoxifen or antiandrogen tx).
Adverse: adrenal insuff, give w/ glucocorticoids

8

Mitotane

Adrenocorticolytic (adrenocortical atrophy)
For: 1ary adrenal carcinoma, some Cushing's remission
Adverse: severe GI
Induces hepatic enzymes

9

Metyrapone

selective inhibitor of corticol synth ezyme, dec aldosterone & cortisol
For: tests of adrenal fx, short term during Cushings determination
ONLY DRUG OK IN PREGNANCY
Adverse: less than mitotane, GI, sedation, dizzi, rash, hirsutism

10

MEfepristone

Anti progesterone, and anti glucocorticoid
For inoperable Cushing's not responding to tx
Adverse: abdo, amenorrhea, fatigue, GI