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Flashcards in Endocrine Deck (10):
0

Bromocriptine

DA agonist - for hyperprolactinemia from pituary adenomas (prolactinomas)

1

Cabergoline

DA agonist - for hyperprolactinemia from pituitary adenomas (prolactinomas)
longer T1/2, more effective, better tolerability profile than bromocriptine

2

Sermorelin

GHRH agonist- used for dx
(Geref)

3

Somatropin

GH agonist - to tx growth failure (GH def, renal disease, Turner), cachexia/Aids wasting. SC or IM daily
Adverse: edema (improves), mskl pain, hyperglycemia, hypothyroidism
CI: DM, hypothyroidism

4

Somatrem

GH agonist - (like Somatropin w/ extra met residue)
to tx growth failure (GH def, renal disease, Turner), cachexia/Aids wasting. SC or IM daily
Adverse: edema (improves), mskl pain, hyperglycemia, hypothyroidism
CI: DM, hyporthyroidism

5

Mecasermin

rhIGF-1 - for pt unresponsive to GH
Uses: IGF-1 deletion/mut, GH receptor mutation, GH Abs.
Adverse: hypoglycemia, cell prolif, +same as GH tx (edema, hypothyroidism)
(Increnex)

6

Mecasermin rinfabate

rhIGF-1 & IGFBP3 (inc T1/2)
Not FDA approved yet, but better than mecasermin
(Iplex)

7

Octreotide

Somatostatin analog (GH antagonist)
Tx: GH excess (acromegaly), Dec size of Hormone secreting tumors (VIP, carcinoid, thyrotropinomas). Tx excessive diarrhea (carcinoid)
Adverse: GI (subsides), Gallstones
Dec release of GI and pituitary hormones

8

Lanreotide

Somatostatin analog (GH antagonist)
Tx: GH excess (acromegaly), dec tumor growth, excessive diarrhea.
Adverse: GI (subsides), gallstones/sludge

9

Pegvisomant

GH receptor antagonist
Tx: GH excess (acromegaly), returns IGF-1 levels to normal (97%)
Adv: growth of GH secreting tumors (no feedback), hepatotoxicity
CI: hepatic disease