ARDS

Question 1

MCC of ARDS?

Answer 1

Sepsis

Question 2

By Berlin Definition, how long between insult & onset of ARDS?

Answer 2

1 week

Question 3

Difference in outcomes in high vs low PEEP stratergies in ARDSNet study?

Answer 3

Higher PEEP had better compliance & P/F ratio, but no difference in mortality, vent free days, or ICU free days.

Question 4

definition of driving pressure?

Answer 4

plateau - peep

Question 5

Effect of lowering driving pressure?

Answer 5

mortality benefit (retrospective data). Decrease in driving pressure by 7 lead to a mortality RR of 1.4.

Question 6

Effect of protocol of recruitment maneuvers followed by titrating PEEP?

Answer 6

Worsened mortality, PTX rates, vent-free days.

Question 7

Effect of HFNC for ARDS?

Answer 7

Improved 90-day mortality, but no change in intubation rates (did help intubation rates for P/F < 220).

Question 8

Effect of conservative IVF on ARDS?

Answer 8

Improved oxygenation & vent-free days & ICU-free days. No mortality difference.

Question 9

Effect of prone positioning in ARDS?

Answer 9

improved mortality if used for at least 16 hours.