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Ashley Flashcards

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1
Q

Translocation t(9;22)

A

CML

(Chronic Myeloid Leukemia)

  • Mainly adults (64+)
  • Associated w/ BCR-ABL hybrid
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2
Q

Translocation (11,22)

A

Ewing’s Sarcoma

  • Patrick Ewing’s Jersey Number is 33. 11 + 22 = 33
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3
Q

Translocation (8,14)

A

Burkitt’s Lymphoma

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4
Q

Translocation (11,14)

A

Mantle Cell Lymphoma

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5
Q

Translocation (15,17)

A

AML M3

(Acute Myeloid Leukemia, Subtype M3)

  • Tx: ATRA more effective against AML M3 subtype
  • Complication: DIC (via breakage of Auer rods)
  • Histo: Auer rods
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6
Q

Translocation (14,18)

A

Follicular Lymphoma

  • BCL-2 (part of the intrinsic apoptotic pathway)
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7
Q

Translocation (12,21)

A

ALL

(Acute Lymphocytic Leukemia)

  • (14,21) Down’s Syndrome acrocentric
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8
Q

DiGeorge Mnemonic

A

CATCH-22

(DiGeorge Syndrome)

  • Cleft palate
  • Abnormal facies
  • Thymic aplasia (T-cell deficiency)
  • Cardiac defects (conotruncal)
  • Hypocalcemia (2/2 parathyroid aplasia—third pharyngeal pouch: inferior parathyroids are grown with thymus and descend together)
  • 22q11: Microdeletion at chromosome 22q11
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9
Q

Causes QRS widening

A

TCA overdose

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10
Q

Dilated pupils, dry & flushed skin, urinary retention, constipation, tachycardia

A

Anticholinergic overdose

(Diphenhydramine overdose)

  • Tx: Physostigmine
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11
Q

Myasthenia Gravis Tx

A

Pyridostigmine

Dx: Tensilon Test (Edrophonium)

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12
Q

AGMA Mnemonic

A

MUDPILES

  • Methanol
  • Uremia
  • DKA
  • Propylene Glycol
  • INH/Iron, Isolyene Glycol
  • Lactic acidosis
  • Ethylene Glycol (antifreeze)
  • Salicylates (late)
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13
Q

NAGMA Mnemonic

A

HARDASS

  • Hyperalimentation (vitamins)
  • Addison disease (primary adrenal insufficiency)
  • RTA
  • Diarrhea
  • Acetazolamide (CA-inhibitor)
  • Spironolactone (MRAs)
  • Saline infusion
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14
Q

Absence of dark blue cytoplasmic staining upon nitroblue tetrazolium administration

A

Chronic Granulomatous Disease (CGD)

  • Absence of dark blue staining indicates defective phagocytosis. In normal phagocytes, phagocytosis will result in dark blue cytoplasmic staining with NBT.
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15
Q

Giant peroxidase-positive granules within neutrophils and platelets

A

Chediak-Higashi Syndrome

Primary immunodeficiency disorder stemming from a defect in the lysosomal trafficking regulator gene, LYST, leading to microtubule dysfunction and failure of phagolysosome formation.

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16
Q

Paraneoplastic Syndromes of SCLC

A
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17
Q

Spherules containing endospores on sputum sample

A

Coccidiomycosis

(hiking in Arizona desert)

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18
Q

Mutation for melanoma

A

BRAF Kinase mutation (missense mutation)

  • Because it is a Valine to Glutamic substitution at V600E
  • Rx: Verumatinib
  • 4 types:
    • Acral lentigo, nodular, superficial,
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19
Q

Monitored to adjust heparin dosing when giving unfractionated heparin to a DVT pt

A

Activated Partial Thromboplastin Time

(For warfarin, it would be INR)

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20
Q

Most common complication of BPH

A

Hydronephrosis

(2/2 the backup of urine)

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21
Q

Growth over eyelid that does not go away with warm compresses. Dx & Tx?

A

Chalazion

Tx: Excision

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22
Q

SOB, UL breath sounds, JVD

A

Tension Pneumothorax

(Tx: Needle Decompression)

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23
Q

You get high calcium with this type of diuretic

A

Thiazides

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24
Q

Pt p/w dark urine and non-pruritic rash on hands. Dx & Tx?

A

Porphyria Cutanea Tarda

Tx: Hydroxychloroquine

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25
Glossitis, stomatitis, dry rash. Vitamin deficiency?
Vitamin B2 Deficiency (Riboflavin)
26
Exposure to this drug is associated with tricuspid valve dysfunction
Fetal exposure to **Lithium**
27
Bilateral temporal hemianopsia
Pituitary tumor Think panhypopituitary symptoms
28
Nephrotic syndrome associated w/ HCV
**Membranoproliferative Glomerulonephritis** (MPGN)
29
Tuft of hair over newborn's lumbosacral region
**Neural tube defect** (Can be 2/2 mother having taken valproate during pregnancy)
30
Tx for Magnesium Sulfate toxicity
**Calcium Gluconate**
31
**Reflexes w/ Magnesium Sulfate**
Hyporeflexia (diminished)
32
Treatment of Torsades de Point
**Magnesium Sulfate** * Drug-induced long QT: ABCDE * Antiarrhythmics (Class IA, III) * Antibiotics (macrolides) * Anti"C"ychotics (e.g. haloperidol) * Antidepressants (e.g. TCAs) * Antiemetics (e.g. ondansetron)
33
Compares means between two groups
**t-test**
34
Bilateral presentation of trigeminal neuralgia
**Multiple Sclerosis** Tx: Steroids then DMARDs(?)
35
Hypotension, distant heart sounds, distended neck veins
**Cardiac tamponade** (+Pulsus paradoxus; +electrical alternans)
36
Responsible for secreting anti-Mullerian hormone during embryogenesis (suppressing development of internal female genitalia)
**Sertoli Cells**
37
Vessel branch most likely the source of esophageal variceal bleeding
L gastric vein (portal circulation) & Azygos vein (systemic circulation)
38
MCC of UTI
**E. coli** then Staph saprophyticus, then Klebsiella
39
PNA with hyponatremia. Organism?
**Legionella** | (Cruises, water mist)
40
IgA attacks parietal cells
**Pernicious Anemia** | (autoimmune)
41
Best method for evaluating for possible cervical incompetence in pregnant pt w/ r/o cervical incompetence
Transvaginal ultrasound at 18 weeks gestation
42
Brisk reflexes = Hyper- or hyporeflexia?
Hyperreflexia
43
A larger circular or ovoid plaque (herald patch) most commonly on the trunk, followed by multiple smaller ovoid lesions which classically arrange themselves on a Christmas tree pattern on the back, sparin gthe face, palms, & soles. (+/- pruritus)
**Pityriasis rosea** | (2/2 HHV-6 or HHV-7)
44
Infection seen more often in sickle cell patients
**Salmonella Osteomyelitis** | (also Staph aureus osteomyelitis)
44
Infection seen more often in sickle cell patients
Salmonella Osteomyelitis
45
Dizziness caused by canalithiasis
**BPPV** * Diagnosed w Dix-Hallpike Maneuver * Treated w/ Epley Maneuver
46
Dizziness caused by increased endolymph production
Meniere's Disease
47
Oligoclonal IgG bands on electrophoresis or LP
**MS** | (Multiple Sclerosis)
48
Reduces exophthalmos symptoms in MG patients
**Prednisone**
49
Drooling in fully-vaccinated child. Organism?
**Strep pneumo**
50
Folate is absorbed in the
**Jejunum** | (B12 in the terminal ileum)
51
Pancreatic pseudocyst - Tx?
**Cystogastrostomy** | (for drainage)
52
Pregestational diabetic in pregnancy requires this monthly until delivery
NST or Biophysical Profile
53
First line drug used to assist in pregnancy in PCOS pts
Letrozole (Aromatase Inhibitor) (Clomiphene citrate is no longer first line)
54
Can haptoglobin be normal in hemolysis?
Yes, in **Extravascular Hemolysis**, such as Acute Splenic Sequestration Crisis, where abnormal sickled RBCs are sequestered in the spleen and can undergo extravascular destruction mediated by immune cells in the spleen, leading to acute anemia.
55
Definitive Tx for HELLP syndrome (Severe Pre-Eclampsia)
**Delivery (CSx)**
56
Pre-surgery Tx in Pheochromocytoma resection
**Phenoxybenzamine** | (irreversible α blockade)
57
Atypical schizophrenia Tx?
**Quetiapine**
57
Atypical schizophrenia Tx?
**Quetiapine**
58
Perimysial CD4+ infiltration and perifascicular atrophy
Dermatomyositis
59
Denervation and reinnervation of the muscle
**ALS** (Neurodegenerative d/o that p/w asymmetric upper & lower motor neuron Sx, w/ preservation of mentation, bowel, bladder, sensory, & sexual function)
60
CD8+ infiltrating wihtin the fascicle
polymyositis
61
Lecithin:Sphingomyelin ratio \<2
**Give betamethasone** (to accelerate fetal lung maturity and increase surfactant production) * \<34 weeks gestation or \<36w + L/S \< 2 → Give betamethasone
62
Tension PTX vs Spontaneous PTX
Spontaneous PTX is ipsilateral; Tx = Chest tube thoracostomy Tension PTX is contralateral; Tx = Needle thoracostomy
63
In pt with DKA, do this BEFORE giving them insulin
IV NS & Potassium
64
Calcium and Phosphate levels in Vitamin D deficiency
**Decreased** | (Hypocalcemia & Hypophosphatemia)
65
What PNA gives you low sodium?
**Legionella**
66
T-cell mediated hypersensitivity
**Type IV Hypersensitivity** | (e.g. Nickel allergy, poison oak)
67
MCC of mortality in burn pts
**Hypovolemia** (2/2 loss of fluid due to impaired skin function)
68
**Poxvirus** (Molluscum Contagiosum) * Tx: Self-limited or cosmetic (curettage or liquid nitrogen)
69
Suspected temporal arteritis in pt p/w fever, HA, ↑ESR, & right scalp tenderness. Next step?
**Start oral prednisone** or they’re going to go blind * Temporal arteritis = GCA (Giant Cell Arteritis)
70
Brazilian/Central American man with lump in his mouth, ulcers, immunocompromised
**Paracoccidioides brasiliensis**
71
Decreased levels of Vitamin D, there is ↓ __ absorption from GI tract, leading to ↓ __ levels
**↓ Calcium** | (↑ PTH)
72
Tumor that is GFAP+
**Glioblastoma**; **Astrocytoma** (stains for astrocytes, Schwann cells, oligodendrocytes)
73
Serum sickness is Type __ Hypersensitivity
**Type III Hypersensitivity** | (Antibody-antigen complex deposition)
74
Male pattern baldness Tx MOA?
**5-α reductase inhibition** (Finasteride; decreases conversion of testosterone to DHT) * Used for BPH and male pattern baldness
75
Achondroplasia mode of inheritance?
**AD** (Autosomal Dominant) * Mutation in fibroblast growth factor receptor (FGFR3) * Increases with increasing paternal age
76
Abnormal development of **1st branchial arch** 2/2 neural crest dysfunction (mandible, middle ear bones, sphenomandibular structures, muscles of mastication, neck muscles including mylohyoid)
**Treacher Collins Syndrome** (p/w mandibular hypoplasia & facial abnormalities)
77
Follows tonic-clonic seizures 2/2 vigorous muscle contraction
**Post-ictal Lactic Acidosis** Tx: Observation as acidosis normalizes
78
Tx for post-ictal lactic acidosis
**Observation** | (as acidosis normalizes on its own)
79
Most common non-melanoma skin cancer in the US
Basal Cell Carcinoma
80
Pink or flesh-colored papule that is pearly or translucent with telangectasias
Basal Cell Carcinoma
81
Narrow M-spike of monoclonal IgM
**Waldenstrom's macroglobulinemia** (10% or more of BM infiltration by clonal lymphoplasmocytic cellsand a monoclonal IgM gammopathy)
82
M-spike of IgA and IgG
Multiple Myeloma
83
Repetitive brief headaches. Excruciating periorbital pain with lacrimation and rhinorrhea. May present with Horner syndrome.
**Cluster HA** (unilateral) Tx: Sumatriptan, 100% O2 PPx: Verapamil
84
Steady pain \> 30 min (typically 4–6 hr); constant. No photophobia or phonophobia. No aura.
**Tension HA** | (Bilateral)
85
CD15 + CD30
Biomarkers for **Hodgkin's Lymphoma**
86
Biomarkers for Hodgkins Lymphoma
**CD15** + **CD30**
87
Bilobed nuclei
**Hodgkin Lymphoma** (Reed Sternberg cells) * Biomarkers CD15, CD30 * B symptoms * Associated w/ EBV
88
Ulcerative red lesion
Squamous Cell Carcinoma * ↑ sun exposure * ↑ immunosuppression * ↑ arsenic exposure * Precursor is actinic keratosis
89
Cholestatic pattern in pt with UC
**PSC** Intra- and extrahepatic bile ducts will be obliterated | (Primary Sclerosing Cholangitis)
90
Acne rosacea Tx
**Topical metronidazole**
91
Patient w/ hypoglycemia in setting of low c-peptide
**Factitious hypoglycemia** due to exogenous insulin administration Factitious Disorder
92
Psoas & Obturator signs are maneuvers that test for
Irritation of the respective muscles by an inflammatory process such as acute appendicitis, a ruptured appendix, or pelvic inflammatory disease (PID)
93
Supplies blood to the Left Atrium and Posterior Left Ventricle
**Left Circumflex Artery (LCX)**
94
Bony Landmark Origin of the ACL?
Posteromedial aspect of the lateral femoral condyle * Insertion is on the anteromedial tibial plateau * ACL tear is tested by Anterior Drawer test & Lachman test
95
Defect in Tyrosinase
**Albinism** Tyrosinase converts DOPA to Melanin DOPA = dihydroxyphenylalanine
96
Gram-positive rod that can be grown at 22°C in pt w/ h/o cancer or renal transplants
**Listeria monocytogenes** * Usually presents as a common cause of meningitis in adults with cancer or h/o renal transplants * **Displays tumbling motility in broth**
97
Decreases synaptic reuptake of norepinephrine and dopamine
**Methylphenidate**
98
Prevents conversion of xanthine to uric acid
**Allopurinol**
99
Inhibits microtubule polymerization
**Colchicine**
100
Drug used to diagnose asthma
**Methacholine**
101
GAA Trinucleotide Repeat
**Friedrich Ataxia** * AR disorder characterized by spinal cord tract degeneration, leading to ataxia, muscle weakness, areflexia, loss of vibratory sense & proprioception, dysarthria, & MSK deformities (e.g. pes cavus, hammertoes, kyphoscoliosis).
102
CAG Trinucleotide Repeat
**Huntington Disease** | (also cause of spinocerebellar ataxia)
103
CGG Trinucleotide Repeat
**Fragile X Syndrome**
104
CTG Trinucleotide Repeat
**Myotonic dystrophy** * p/w “loss of hand grip”, frontal baldness
105
45XO
**Turner Syndrome**
106
47XYY
**Jacob Syndrome ("Supermale Syndrome")** * Klinefelter is 47XXY

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