Atorvastatin Flashcards
1
Q
What class of drug is atorvastatin?
A
Statin
2
Q
What are the uses of atorvastatin?
A
Primary + secondary prevention of CVD
Hypercholesterolaemia
3
Q
What is the mechanism of action of atorvastatin?
A
statin
- competitively inhibits HMG-CoA reductase
- reduces cholesterol synthesis
.
- increases LDL receptor on hepatocytes
4
Q
What are the adverse effects of atorvastatin?
A
- GI disruption - N+V
- myalgia
- rhabdomyolysis (rare)
5
Q
What are the contraindications of atorvastatin?
A
Pregnancy + breast feeding
Hepatic or renal impairment
6
Q
What are important drug drug interactions with atorvastatin?
A
Amlopidine
CYP 3A4 inhibitors e.g. grapefruit juice, amiodarone, Diltiazem, macrolides (clarithromycin)
