Audia: Hepatitis ILA

Question 1

the major problem for viral hepatitis

Answer 1

chronic liver disease and HCC

Question 2

picornavirus
acute diease

Answer 2

HAV (Hep A virus)

Question 3

2 enteric acute diseases

Answer 3

HAV and HEV

Question 4

hepadnavirus
acute
chronic/cancer

Answer 4

HBV (hep B virus)

Question 5

flavivirus (RNA)
acute, chronic/cancer

Answer 5

HCV

Question 6

RNA virus
co-infection with HBV
chronic/fulminant

Answer 6

HDV

Question 7

oral-fecal transmission
infectious hepatitis
NO chronic or carrier state

Answer 7

Hepatitis A

Question 8

2-4 wk incubation (IgM then IgG)

Answer 8

Hepatitis A

Question 9

naked capsid
+ssRNA

Answer 9

HAV

Question 10

replication of HAV:

Answer 10

receptor mediated endocytosis
uncoat and RNA released in cytoplasm
single polyprotein made and chopped up by protease into functional subunits

Question 11

type of virus that is ready to be translated once it gets into host cell cytoplasm

Answer 11

+ssRNA

Question 12

extremely stable due to no envelope

Answer 12

Hep A

Question 13

sx’s of fever, fatigue, nausea, abd pain occur abruptly

Answer 13

Hep A

Question 14

incubation period is average of 30 days

Answer 14

Hep A

Question 15

can see jaundice within 2-4 wks as compared to hep B 1-6 months

Answer 15

Hep A

Question 16

close personal contact
contaminated food/water (shellfish)!
blood exposure (rare)

Answer 16

Hep A

Question 17

to dx:
time course of sx’s
identify source
serology

Answer 17

Hep A

Question 18

best way to prevent Hep A

Answer 18

vaccine

Question 19

hepadnavirus
spreads by blood/bodily fluids

Answer 19

Hep B

Question 20

can lead to chronic disease and HCC

Answer 20

Hep B

Question 21

“serum hepatitis”

Answer 21

Hep B

Question 22

enveloped virus
dsDNA genome
has surface Ag

Answer 22

Hep B

Question 23

surface antigen for Hep B that actually breaks off as well with the Hep B virus from host cell and acts as decoy to host Ab’s so Hep B can prevail

Answer 23

HBsAg

Question 24

surface antigen used for HBV vaccine

Answer 24

HBsAg

Question 25

soluble antigen of HBV and associated with replication

Answer 25

HBeAg

Question 26

core antigen that will bind with host Ab and indicate carrier/chronic infection

Answer 26

HBcAg

Question 27

Hep B replication

Answer 27

into host cell (becomes a part of host genome) uncoat reverse transcriptase makes more virus HBV and HBsAg released

Question 28

how do people become carriers of Hep B

Answer 28

if exposed and have weak T cell response (mild sx's but won't clear virus)

Question 29

jaundice from liver damage 1-6 months post infection

Answer 29

Hep B

Question 30

10% of these cases become chronic (cirrhosis)

Answer 30

Hep B

Question 31

____% of cases of HCC have viral cause

Answer 31

80%

Question 32

long incubation (3 months ave) insidious onset prodromal phase

Answer 32

Hep B acute infection

Question 33

classic icteric sx's of liver damage

Answer 33

jaundice, dark urine, pale stool

Question 34

fulminant disease of HBV when co-infected with what

Answer 34

HDV

Question 35

what type of hypersensitivity rxns can be associated with Hep B

Answer 35

type III (immune complexes)

Question 36

detected by liver enzymes

Answer 36

Hep B chronic infection

Question 37

____% of patients develop cirrhosis or liver failure

Answer 37

10%

Question 38

80% of all HCC is due to what

Answer 38

HBV

Question 39

HBV has integration of viral genome into what

Answer 39

host hepatocyte DNA

Question 40

Hep B transmission

Answer 40

sexual parenteral perinatal

Question 41

Dx w/ clinical sx's elevated liver enzymes serology and virus proteins

Answer 41

Hep B

Question 42

Rx/prevent Hep B

Answer 42

HBsAg Hep B vaccine

Question 43

ssRNA requires co-infection with HBV

Answer 43

HDV (Hep D)

Question 44

host RNAPII makes RNA copy replicates genome, makes mRNA genome is ribozyme

Answer 44

replication for Hep D

Question 45

blood/bodily fluids transmission co-infection

Answer 45

Hep D

Question 46

Dx Hep D

Answer 46

ELISA for delta Ag or Ab

Question 47

flavivirus difficult to culture 1-6 month incubation period can cause chronic disease

Answer 47

Hep C

Question 48

+RNA genome enveloped

Answer 48

Hep C

Question 49

how to make drugs against viruses

Answer 49

selective toxicity

Question 50

Hep C replication:

Answer 50

Bind to receptor and gets in by endocytosis Endosome w/ lysosome and pH drops and helps un-coat and release ribonucleic acid into cytoplasm Replicate and make polyproteins-----then chopped up by protease to make functional pieces Leave host cell through exocytosis

Question 51

main mechanism of immune avoidance for Hep C

Answer 51

antigenic drift (error prone replication and causes mutations)

Question 52

____ are the reservoirs for HCV

Answer 52

humans

Question 53

Ab to HCV not protective why

Answer 53

antigenic drift

Question 54

60-85% likelihood of chronic infection

Answer 54

Hep C

Question 55

no vaccine for this

Answer 55

Hep C

Question 56

dx by ELISA

Answer 56

hep C

Question 57

_____ has to have an external coat of Hep B before it can infect hepatocytes and multiply

Answer 57

Hep D