Sos- Liver Dysfunction Flashcards

(107 cards)

1
Q
A

blood in liver

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2
Q
A

hemangioma

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3
Q
A

gas in gallbladder

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4
Q
A

diaphragmatic hernia

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5
Q

a diaphragmatic congenital defect allowing stomach, intestines, and liver to herniate in chest

A

diaphragmatic hernia

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6
Q
A

jaundice (icterus)

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7
Q

jaundice is a yellow pigmentation of skin due to what

A

increased levels of bilirubin in the blood (b/c it is not being secreted into bile)

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8
Q

jaundice is also associated with _______

A

pruritis

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9
Q

toxic levels of bilirubin accumulate in basal ganglia and thalamus

A

Kernicterus (Bilirubin Encephalopathy)

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10
Q
A

bilirubin encephalopathy

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11
Q

infant has fever, trouble feeding, and muscle spasms

A

Kernicterus (Bilirubin Encephalopathy)

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12
Q
A

acetaminophen toxicity

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13
Q
A

acetaminophen toxicity

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14
Q

most common drug-induced liver injury in the US

A

acetaminophen

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15
Q

this drug-induced liver injury involves necrosis of zone 3 and 2

A

acetaminophen toxicity

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16
Q

acute illness that causes liver and brain damage due to viral infection

A

Reye’s syndrome

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17
Q

13 yr old recovering from the flu experiences confusion, seizures, and loss of consciousness

A

Reye’s Syndrome

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18
Q

steatosis and hepatitis

A

Reye’s syndrome

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19
Q

fat stained with what

A

Oil red O or PAS

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20
Q

____ used for fever or pain has been linked to Reye’s syndrome

A

Aspirin

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21
Q

vitamins stored in the liver

A

A, D, E, K, B12

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22
Q

___ and ___ are essential for absorbing the fat-soluble vitamins

A

fat breakdown and bile secretion

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23
Q

stored in stellate cells; important for eye health, skin, intestines, lungs, and immune system

A

Vitamin A

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24
Q

primary role is Ca2+ absorption and bone health

A

vitamin D

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25
primary role is as an antioxidant
vitamin E
26
required to make prothrombin involved in blood clotting
vitamin K
27
naturally found in meats and important in brain functions and RBC synthesis
vitamin B12
28
atleast 20 yr alcohol abuse
alcohol-related liver disease
29
elevated AST>ALT (2:1)
alcohol-related liver disease
30
stages of alcohol liver disease
steatosis steatosis + hepatitis fibrosis (cirrhosis)
31
normal liver
32
steatosis
33
steatohepatitis
34
fibrosis (cirrhosis)
35
damaged cytokeratin filaments
mallory bodies (seen in alcohol liver disease)
36
pt has fever, RUQ pain, and jaundice elevated AST/ALT (AST>ALT) direct hyperbilirubinemia
alcoholic hepatitis
37
cirrhosis
38
liver parenchyma replaced with scar tissue (chronic condition initiated by alcohol abuse)
alcohol-induced cirrhosis
39
patient has 20 yr hx of alcohol abuse and has weight loss, jaundice, edema, pale stool, confusion
alcohol-induced cirrhosis
40
micronodular
alcohol induced cirrhosis
41
cirrhosis
42
increase in bp in the portal-systemic collaterals
portal HTN
43
3 types of portal HTN
1. prehepatic 2. intrahepatic 3. post-hepatic
44
esophageal varices
45
problem w/ esophageal varices
can rupture and bleed
46
ascites
47
ascites
48
caput medusae
49
edema secondary to obstruction of vascular flow
ascites
50
ascites + infection
spontaneous bacterial peritonitis
51
primary cancer of liver will live in _____livers
cirrhotic
52
hepatocellular carcinoma
53
hepatocellular carcinoma
54
____ used for screening/diagnosis/prognosis of HCC
alpha-fetoprotein (AFP)
55
most common benign liver tumor
hemangioma
56
mass of abnormal blood vessels
hemangioma
57
liver hemangioma
58
young women w/ long hx of oral contraceptives; complications are hemorrhage
hepatic adenoma
59
hepatic adenoma
60
most common malignant liver cancer
metastatic neoplasm
61
metastatic neoplasm
62
metastatic neoplasm
63
a consequence of metabolic syndrome
metabolic dysfunction associated steatotic liver disease (MASLD)
64
elevated liver enzymes ALT>AST can lead to cirrhosis
MASLD
65
rare disorder deals w/ obstruction of hepatic venous outflow + presence of intrahepatic collateral vessels and hypervascular nodules (thrombotic or non-thrombotic)
Budd-Chiari syndrome
66
cirrhosis w/ HCC
67
Budd-Chiari syndrome
68
ages 20-50 chronic lung disease
alpha-1 antitrypsin deficiency
69
lungs lack this buildup of this in liver
alpha-1 antitrypsin
70
enzyme that gets trapped in liver due to reduced synthesis or protein folding (lung and liver damage)
alpha-1 antitrypsin
71
enzyme that damages lungs due to alpha-1 antitrypsin deficiency
neutrophil elastase
72
alpha-1 antitrypsin deficiency
73
globules of alpha-1 antitrypsin
74
over absorption of iron white men
hereditary hemochromatosis
75
mutation in HFE gene fatigue, joint and abd pain
hereditary hemochromatosis
76
lack of _____, so overabsorption of iron
hepcidin
77
serum iron bound to transferrin
serum iron
78
made by liver and transports iron in blood
transferrin
79
soluble iron storage protein found in macrophages
ferritin
80
percentage of binding sites on transferrin occupied by iron
% transferrin saturation
81
third box dx?
hemochromatosis
82
hereditary hemochromatosis
83
stain for iron
Prussian blue
84
arthropathy + bronzing of skin
hereditary hemochromatosis
85
what organ
pancreas
86
too much copper stored in liver, brain, and corneas
Wilson Disease
87
psychiatric manifestations and movement disorders and liver dx symptoms
Wilson disease
88
Kayser-Fleischer ring (Wilson Disease)
89
mutation of ____ gene important in movement of excess copper from liver to bile
ATP7B
90
stain for copper
Rhodanine
91
Wilson disease
92
basal ganglia damage (Wilson disease)
93
basal ganglia damage seen in wilson disease
Hepatolenticular degeneration
94
multisystem disease involving liver, pancreas, kidneys, and lungs
Cystic Fibrosis
95
mutation in CF gene and produces thick mucus throughout body
Cystic Fibrosis
96
pancreas
CF of pancreas (thick mucus seen)
97
liver
CF of liver (thick mucus seen)
98
2nd most common abd injury involves round ligament and triangular ligament
liver trauma
99
Morrison's pouch (hepatorenal)
100
most dependent part of abdominal cavity, in SUPINE position, for fluid collection
morrison's pouch
101
b/t uterus and rectum and is the most dependent part of abdominal cavity STANDING for fluid collection
pouch of Douglas (rectouterine/rectovesicular)
102
perisplenic space
103
liver fxn declines w/ __
age
104
lipofuscin accumulation
aging effects on liver
105
inflammation replaced by portal triad fibrosis and then bridging fibrosis (due to virus)
viral hepatitis
106
viral hepatitis
107
productive cough recurrent sinopulmonary infections pancreatic insufficiency
Cystic Fibrosis