Autoantibodies Flashcards

1
Q

anti-IgG antibodies

A

rheumatoid arthritis

IgM antibody specific to IgG Fc region

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2
Q

anti-citrullinated protien antibodies (ACPA)/anti-CCP

A

rheumatoid arthritis

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3
Q

anti-centromere antibodies

A

CREST syndrome (limited scleroderma)

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4
Q

anti-Scl-70 (anti-DNA topoisomerase I)

A

Scleroderma (diffuse)

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5
Q

anti-histone

A

drug-induced lupus

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6
Q

antinuclear antibodies (ANA)

A

SLE, nonspecific

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7
Q

anti-Smith (anti-dsDNA)

A

SLE

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8
Q

anti-Jo-1, anti-SRP, anti-Mi-2

A

polymyositis

dermatomyositis

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9
Q

anti-SSA (anti-Ro), anti-SSB (anti-La)

A

Sjogren syndrome

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10
Q

anti-U1-RNP

A

mixed connective tissue disease

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11
Q

anti-desmoglein

A

pemphigus vulgaris

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12
Q

anti-acetylcholine receptor

A

myasthenia gravis

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13
Q

IgA anti-endomysial (anti-tissue transglutaminase)

A

Celiac disease

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14
Q

anti-gliadin

A

Celiac disease

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15
Q

anti-mitochondrial

A

primary biliary cirrhosis

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16
Q

anti-smooth muscle

A

autoimmune hepatitis

17
Q

anti-glutamate decarboxylase

A

type I DM

18
Q

anti-thyrotropin receptor

A

Graves disease

19
Q

anti-thyroid peroxidase (anti-TPO)

A

Hashimoto thyroiditis

20
Q

anti-thyroglobulin

A

Hashimoto thyroiditis, Graves disease

21
Q

anti-basement membrane

A

Goodpasture syndrome

22
Q

c-ANCA (PR3-ANCA)

A

Granulomatosis with polyangiitis (Wegener)

23
Q

p-ANCA (MPO-ANCA)

A

pauci-immune crescentic glomerulonephritis
Churg-Strauss syndrome
Microscopic polyangiitis

24
Q

anti-hemidesmosome

A

bullous pemphigoid