Autoantibodies

Question 1

Anti-Ach receptor

Answer 1

Myasthenia gravis

Question 2

Anti-basement membrane

Answer 2

Goodpasture syndrome

Question 3

Anticardiolipin, lupus anticoagulant

Answer 3

SLE, Antiphospholipid syndrome

Question 4

Anticentromere

Answer 4

Limited scleroderma (CREST syndrome)

Question 5

Anti-desmosome (anti-desmoglein)

Answer 5

Pemphigus vulgaris

Question 6

Anti-dsDNA, anti-Smith

Answer 6

SLE

dsDNA=>Damaged Nephrons

Question 7

Anti-glutamic acid decarboxylase (GAD-65)

Answer 7

Type 1 DM

Question 8

Antihemidesmosome

Answer 8

Bullous pemphigoid

Question 9

Anti-histone

Answer 9

Drug-induced Lupus

Question 10

Anti-Jo-1, anti-SRP, anti-Mi-2

Answer 10

Polymyositis, dermatomyositis

Question 11

Antimicrosomal, antithyroglobulin

Answer 11

Hashimoto thyroiditis

Question 12

Anti-mitochondrial

Answer 12

Primary Biliary Cirrhosis

Question 13

Anti-nuclear antibodies

Answer 13

SLE, Nonspecific

Question 14

Anti-parietal cell

Answer 14

Pernicious anemia

Question 15

Anti-Scl-70 (anti-DNA topoisomerase)

Answer 15

Scleroderma (Diffuse)

Question 16

Anti-smooth muscle

Answer 16

Autoimmune hepatitis

Question 17

Anti-SSA, Anti-SSB (Anti-Ro, Anti-La)

Answer 17

Sjorgen Syndrome

Question 18

Anti-TSH receptor

Answer 18

Graves Disease

Question 19

Anti-U1 RNP

Answer 19

Mixed connective tissue disease

Question 20

IgA anti-endomysial, IgA anti-tissue transglutaminase

Answer 20

Celiac Disease

Question 21

MPO-ANCA/p-ANCA

Answer 21

Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

Question 22

PR3-ANCA/c-ANCA

Answer 22

WeCener’s granulomatosis (granulomatosis with polyangiitis)

Question 23

Rheumatoid Factor(IgM Ab against IgG Fc Region) *non specific, anti-CCP (more specific)

Answer 23

Rheumatoid arthritis