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FINALS - RHEUM > autoimmune connective tissue > Flashcards

autoimmune connective tissue Flashcards

1
Q

who usually gets SLE

A

black females, 20-40

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2
Q

what type of hypersensitivity disease is SLE

A

type III

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3
Q

genetic assoc SLE

A

HLA b8, DR2, DR3

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4
Q

general features SLE

A

fatigue, fever, mouth uclers, lymph

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5
Q

skin features SLE (5)

A

malar (butterfly rash) // discoid rash (scaly) // photosensitive // non-scarring alopecia // reynauds

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6
Q

MSK + neuro features SLE

A

arthalgia (morning stiffness 2+ joints // psychosis, depression, seizures

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7
Q

resp cardio renal symptoms SLE

A

pericarditis, pleurisy, leukopenia

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8
Q

antibodies SLE

A

ANA!! // anti ds DNA // anti SM, Ro, La

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9
Q

blood invx SLE

A

ESR, CRP // C3, C4

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10
Q

what can raised CRP in SLE indicate

A

infection

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11
Q

what bloods are seen in active SLE

A

LOW C3/4

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12
Q

lifestyle mx SLE

A

suncream, avoid oestrogen contraception

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13
Q

first line mx SLE

A

NSAIDs + hydroxychloroquine

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14
Q

mx severe organ involvement SLE

A

cyclophosphamide

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15
Q

what can cause sjorgens

A

primary or secondary to other autoimmune connective disorders eg RA

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16
Q

Who gets sjorgens

A

females

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17
Q

what cancer is increased in sjorgens

A

lymphoid

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18
Q

symptoms sjorgens

A

dry mucous membranes: conjunctivitis, dry mouth, vaginal dryness, arthlagia, reynaulds

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19
Q

what test can be done for dry eyes in sjorgens

A

shirmers

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20
Q

antibodies sjorgens

A

ANA // anti ro + la // RF

21
Q

mx sjorgens

A

pilocarpine (for salilva) –> Hydroxychloroquine
–> Cyclophosphamide

22
Q

who gets systemic sclerosis

A

women

23
Q

general systemic sclerosis symtoms

A

reynauds, dysphagia, gord, telangectasia, puckered lips, tight face (no wrinkles)

24
Q

what is limited systemic sclerosis

A

extremeties/ distal limbs + face

25
Q

symptoms limited systemic sclerosis

A

CREST: calcinosis, reynaids, oEsophageal dysmotility, sclerodactyly, telangectasia

26
Q

antibody in diffuse vs limited systemic sclerosis

A

limited = anti-centromere + ANA // diffuse = anti-scl + ANA

27
Q

symptoms diffuse systemic sclerosis

A

pulm hypertension + ILD // renal disease // malabsorption

28
Q

biggest cause of death diffuse systemic sclerosis

A

lung disease (hypertension)

29
Q

mx renal disease in diffuses systemic sclerosis

A

ACEi

30
Q

symptoms scleroderma

A

skin changes without organ involvement // skin tightening, tight lips, plaques

31
Q

mx systemic sclerosis

A

CCBs // ACEi (renal damage) // cyclophosphamide

32
Q

what drug should not be ised in systemic sclerosis

A

steroids (in case of renal damage)

33
Q

what is reynauds

A

vasconstriction of digital arteries in response to cold/ stress

34
Q

what is primary reynauds called

A

reynauds disease

35
Q

what is secondary reynauds called

A

reynauds phenomenon

36
Q

who gets reynauds disease

A

young women with bilateral symptoms

37
Q

secondary causes of reynauds

A

connective tissue eg scleroderma, RA, lupus // leukaemia // vibrating tools // COCP // cryoglobulinaemia

38
Q

mx reynauds

A

CCB eg nifedipine // IV prostacyclin

39
Q

symptoms APS

A

arterial and venous thromboses // recurrent miscarriage // thrombocytopenia (low platelets // livedo reticularis // migraines // pre-eclampsia

40
Q

secondary causes APS

A

lupus

41
Q

risks assoc with APS

A

stroke, MI, PE, hypertension

42
Q

bloods (2) + antibodies APS (3)

A

anticardiolipin, lupus anticoagulant, anti Bs // thrombocytopenia // prolonged APTT

43
Q

mx for patients with APS that have NOT had a thromboses

A

low dose aspirin

44
Q

mx APS with previous VTE

A

lifelong warfarin (INR 2-3)

45
Q

mx APS in pregnancy

A

aspirin + heparin

46
Q

symptoms drug induced lupus (4)

A

arthritis, myalgia, malar rash, pleurisy

47
Q

antibodies drug lupus

A

ANA positive but anti-DNA negative // anti histone positive

48
Q

features Antisynthetase syndrome

A

mucosity // lung disease // cracked hands // reynauds

49
Q

antibodies Antisynthetase syndrome

A

anti jo

FINALS - RHEUM (8 decks)

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