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FINALS - RHEUM > autoimmune connective tissue > Flashcards

autoimmune connective tissue Flashcards

(49 cards)

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1
Q

who usually gets SLE

A

black females, 20-40

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2
Q

what type of hypersensitivity disease is SLE

A

type III

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3
Q

genetic assoc SLE

A

HLA b8, DR2, DR3

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4
Q

general features SLE

A

fatigue, fever, mouth uclers, lymph

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5
Q

skin features SLE (5)

A

malar (butterfly rash) // discoid rash (scaly) // photosensitive // non-scarring alopecia // reynauds

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6
Q

MSK + neuro features SLE

A

arthalgia (morning stiffness 2+ joints // psychosis, depression, seizures

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7
Q

resp cardio renal symptoms SLE

A

pericarditis, pleurisy, leukopenia

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8
Q

antibodies SLE

A

ANA!! // anti ds DNA // anti SM, Ro, La

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9
Q

blood invx SLE

A

ESR, CRP // C3, C4

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10
Q

what can raised CRP in SLE indicate

A

infection

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11
Q

what bloods are seen in active SLE

A

LOW C3/4

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12
Q

lifestyle mx SLE

A

suncream, avoid oestrogen contraception

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13
Q

first line mx SLE

A

NSAIDs + hydroxychloroquine

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14
Q

mx severe organ involvement SLE

A

cyclophosphamide

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15
Q

what can cause sjorgens

A

primary or secondary to other autoimmune connective disorders eg RA

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16
Q

Who gets sjorgens

A

females

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17
Q

what cancer is increased in sjorgens

A

lymphoid

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18
Q

symptoms sjorgens

A

dry mucous membranes: conjunctivitis, dry mouth, vaginal dryness, arthlagia, reynaulds

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19
Q

what test can be done for dry eyes in sjorgens

A

shirmers

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20
Q

antibodies sjorgens

Study These Flashcards
A

ANA // anti ro + la // RF

21
Q

mx sjorgens

Study These Flashcards
A

pilocarpine (for salilva) –> Hydroxychloroquine
–> Cyclophosphamide

22
Q

who gets systemic sclerosis

23
Q

general systemic sclerosis symtoms

Study These Flashcards
A

reynauds, dysphagia, gord, telangectasia, puckered lips, tight face (no wrinkles)

24
Q

what is limited systemic sclerosis

Study These Flashcards
A

extremeties/ distal limbs + face

25
symptoms limited systemic sclerosis
CREST: calcinosis, reynaids, oEsophageal dysmotility, sclerodactyly, telangectasia
26
antibody in diffuse vs limited systemic sclerosis
limited = anti-centromere + ANA // diffuse = anti-scl + ANA
27
symptoms diffuse systemic sclerosis
pulm hypertension + ILD // renal disease // malabsorption
28
biggest cause of death diffuse systemic sclerosis
lung disease (hypertension)
29
mx renal disease in diffuses systemic sclerosis
ACEi
30
symptoms scleroderma
skin changes without organ involvement // skin tightening, tight lips, plaques
31
mx systemic sclerosis
CCBs // ACEi (renal damage) // cyclophosphamide
32
what drug should not be ised in systemic sclerosis
steroids (in case of renal damage)
33
what is reynauds
vasconstriction of digital arteries in response to cold/ stress
34
what is primary reynauds called
reynauds disease
35
what is secondary reynauds called
reynauds phenomenon
36
who gets reynauds disease
young women with bilateral symptoms
37
secondary causes of reynauds
connective tissue eg scleroderma, RA, lupus // leukaemia // vibrating tools // COCP // cryoglobulinaemia
38
mx reynauds
CCB eg nifedipine // IV prostacyclin
39
symptoms APS
arterial and venous thromboses // recurrent miscarriage // thrombocytopenia (low platelets // livedo reticularis // migraines // pre-eclampsia
40
secondary causes APS
lupus
41
risks assoc with APS
stroke, MI, PE, hypertension
42
bloods (2) + antibodies APS (3)
anticardiolipin, lupus anticoagulant, anti Bs // thrombocytopenia // prolonged APTT
43
mx for patients with APS that have NOT had a thromboses
low dose aspirin
44
mx APS with previous VTE
lifelong warfarin (INR 2-3)
45
mx APS in pregnancy
aspirin + heparin
46
symptoms drug induced lupus (4)
arthritis, myalgia, malar rash, pleurisy
47
antibodies drug lupus
ANA positive but anti-DNA negative // anti histone positive
48
features Antisynthetase syndrome
mucosity // lung disease // cracked hands // reynauds
49
antibodies Antisynthetase syndrome
anti jo

FINALS - RHEUM (8 decks)

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