RA + OA (+ septic) Flashcards
(37 cards)
which joints are usually affected in RA
hands (PIPs + MCPs) and feet
presentation RA
stiffness worse in mornings + better when warmed up, progresses to bigger joints
what hand deformities can be seen in late RA
swan and boutonniere deformites
what antibodies are tested for in RA
anti-CCP (most sensitive) + RF (first test)
what imaging should be done in all patients with suspected RA
Xray hands and feet
what imaging for synovitis can be done in RA
USS - good in early disease
what can determine active disease in RA
DAS28 score + CRP
what bloods may be seen in RA
raised CRP/ ESR and low Hb
what genetics are assoc with RA
HLA DRB1
what is the squeeze test in RA
squeeze MCPs –> pain
what are poor prognostic factors for RA
anti-CCP // RF // X ray changes in 2 years // extra-articlar disease // male
who normally gets RA
females 30-50
early X ray findings RA
loss of joint space, soft tissue swelling, juxta-articular osteoporosis (thinning of bone)
late Xray RA
periarticular erosion, subluxation
extra-articular complications RA (6)
pulm fibrosis + effusions // keratoconjunctiviitis, scleritis // osteoporosis // CV risk // depression
what is felty’s syndomre
RA + splenomegaly + low WCC
initial mx RA
DMARD monotherapy + short course of pred
what DMARDs are used in RA
1) methotrexare // sulfalazine, leflunomide, hydroxychloroquine
what should always be given alongside methotrexate
5mg folic acid
what monitoring needs to be done with methotrexare
FBC (mylosuprresion) + LFT’s (cirrhosis)
when would biologics be given in RA
2 failed DMARDs
what bioligcs can be given in RA (2)
anti-TNF (etanercept or infliximab)
mechanism of OA vs RA
OA = wear and tear // RA = autoimmune
which joints are usually affected in OA
large weight bearing joints (DID and PIP) // foot
