muscle conditions

Question 1

difference between polymyositis and dermatomyositis

Answer 1

dermatomyositis has skin involvement polymositis does not

Question 2

what cells regulate polymyositis/ dermatomyositis

Answer 2

T8 autoimmune

Question 3

what underlying disease can be assoc with polymyositis/ dermatomyositis

Answer 3

malignancy

Question 4

symptoms polymositis

Answer 4

PROXIMAL muscle weakness // reynauds // resp muscle weakness // ILD// dysphagia

Question 5

antibodies polymyositis/ dermatomyositis

Answer 5

anti Jo + anti Mi-2 (+/- ANA)

Question 6

bloods and diagnosis polymyositis/ dermatomyositis

Answer 6

raised CK, (LDH, AST, ALT) // EMG // Muscle biopsy!!

Question 7

mx mild –> severe polymyositis/ dermatomyositis

Answer 7

1) high dose steroids 2) immunosuppressants (azathioprine, methotrexate) 3) IV Ig 4) rituximab

Question 8

skin features dermatomyositis

Answer 8

gottrons papules (hands), helitrope rash on eyelids, shawl sign rash (neck and shoulders), very dry and cracked hands

Question 9

symptoms polymyalgia rheumatica

Answer 9

older patient, rapid onset, morning proximal stiffness (NOT weakness), polyarthralgia, tired, night sweats

Question 10

invx polymyalgia rheumatica

Answer 10

raised inflamm (ESR + CRP (CK normal))

Question 11

assoc with polymyalgia rheumatica

Answer 11

GCA

Question 12

mx polymalgia rheumayica

Answer 12

pred (15mg) - should respond v quickly

Question 13

who gets fibromyalgia

Answer 13

women 30-50

Question 14

symptoms fibromyalgia

Answer 14

chronic pain in multipple places, tired, cognitive ‘fog’, bad sleep, migraines, IBS

Question 15

mx fibromyalgia

Answer 15

exercise, CBT, meds: pregabalin, duloxetine, amitriptyline

Question 16

antibodies in antisyhthetase syndrome

Answer 16

anti-Jo

Question 17

symptoms antisythetase syndrome

Answer 17

myositis, ILD, thickened and cracked hands, reynauds

Question 18

inheritance of McArdles

Answer 18

autosomal recessive

Question 19

pathophysiology McArdles

Answer 19

glycogen V storage issue - myophosphorlase deficiency