Misc (gout, ehler's-danlos, stills, behcets) Flashcards
(50 cards)
what is Behcet’s syndrome
autoimmune –> arteries and veins
who gets Behcet’s
eastern med eg turkey // men // 20-40 // FH
gene assoc with Behcets
HLA B51
triad of Behcets
oral ulcers, genital ulcers, anterior uveitis
other symptoms behcets
thrombophlebiti, DVT, arthritis, aseptic meningitis, GI stuff, erythema nodosum
what is chronic fatigue syndrome
3 months of fatigue affecting medical and phyiscal function (usually idiopathic)
symptoms chronic fatigue
sleep problems // muscle or joint pain // headache // lymph // sore throat // cognitive fig // flu symptoms // dizzy
invx chronic fatigue
diagnosis of exclusion
mx chronic fatigue
CBT, exercise therapy, low dose amitrip
who gets still’s
15-25 or 35-46
symptoms stills
arthralgia // pink rash // pyrexia (worse at end of day) // lymph
diagnosis still’s
raised ferritin // Yamaguchi criteria
mx stills
NSAIDs –> steroids –> methotrexate, anti TNF
inheritance marfans
autosomal dominant
genes marfans
protein fibrillin 1
aesthetic symptoms marfans
tall, long arms // high palate // long fingers // pectus excatavum // flat feet // scoliosis // blue sclera
internal symptoms marfans
mitral valve prolapse // dilation of aortic sinus –> AA, aosrtic dissection, regurg // pneumothorax // lens dislocation // dural ectasia
mx marfans
regular echo, ACEi, BB
biggest cause of death marfans
heart problems
inheritance ehlers danlos
autosomall dominant
gene in ehlers danlos
type III collagen
symptoms ehlers danlos
elastic skin, joint hypermobility, easy bruising, aortic regurg, SAH!!
what causes gout
build up of purines and guanine –> hyperuricaemia
symptoms acute gout
pain, swelling, redness, painful, one joint affected
