Autoimmunity Flashcards

For each disease list self antigen and resulting (inappropriate) immune response

1
Q

Addison’s disease

A

self antigen to adrenal cells

autoantibody response

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2
Q

Autoimmune haemolytic anaemia

A

self antigen to RBC membrane proteins

autoantibody response

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3
Q

Goodpasture’s syndrome

A

self antigen to renal and lung basement membranes

autoantibody response

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4
Q

Hashimoto’s thyroiditis

A

self antigen to thyroid proteins

autoantibodies, T cell response

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5
Q

Grave’s disease

A

self antigen to TSH receptor

autoantibody response

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6
Q

Idiopathic thrombocytopenia

A

self antigen to platelet membrane proteins

autoantibody response

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7
Q

Insulin-dependant diabetes

A

self antigen to pancreatic beta cells

autoantibodies, T cell response

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8
Q

Myasthenia gravis

A

self antigen to acetylcholine receptors

autoantibody response

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9
Q

Pernicious anaemia

A

self antigen to intrinsic factor

autoantibody response

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10
Q

Post-streptococcal glomerulonephritis

A

self antigen to kidney

immune complex response

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11
Q

Spontaneous infertility

A

self antigen to sperm

autoantibody response

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12
Q

Ankylosing spondylitis

A

self antigen to vertebrae

immune complex response

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13
Q

Multiple sclerosis

A

self antigen to brain or white matter

autoantibodies, T cell response

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14
Q

Rheumatoid arthritis

A

self antigen to connective tissue, IgG

immune complex response

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15
Q

Scleroderma

A

self antigen to nuclei, heart, lung, GIT, kidney

autoantibody response

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16
Q

Systemic lupus erythrematosus

A

self antigen to DNA, nuclear proteins, RBCs

immune complex response