HLA associations Flashcards by Emily Wilson

Q

systemic lupus erythematosus

A

HLA DR/W2, DR/W3 and HLA B8, HLA DR3

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Q

dermatomyositis herpetiformis

A

HLA B8/DR3

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Q

kaposi’s sarcoma

A

HLA DR5/DR2

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Q

chronic active hepatitis

A

HLA DR3

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Q

grave’s disease

A

HLA DR3

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Q

myaesthenia gravis

A

HLA DR3

HLA B8

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Q

Addinson’s disease

A

HLA DR3

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Q

Sjogren’s syndrome

A

HLA DR3

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Q

ideopathic membranous nephropathy

A

HLA DR3

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Q

goodpasture’s syndrome

A

HLA DR2

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Q

narcolepsy

A

HLA DR2

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Q

multiple sclerosis

A

HLA DR2

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Q

juvenile insulin dependant diabetes

A

HLA DR3, 4 (positive association), HLA-DR2 (negative association)

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Q

coeliac disease

A

HLA DQ2/8, DR3/7/11

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Q

idiopathic haemachromatosis

A

HLA A3/B14

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Q

schizophrenia

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A

HLA A28

Q

Behcet’s disease

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A

HLA B5

Q

IBD associated arthritis (UC)

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A

HLA B5

Q

ankylosing spondylitis

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A

HLA B27

Q

psoriatic arthropathy

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A

HLA B27

Q

Retter’s disease

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A

HLA B27

Q

Reactive arthritis (including Reiter’s)

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A

HLA B27

Q

Rheumatoid arthritis

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A

HLA DR4

Q

Hashimoto’s disease

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A

HLA DR5 ?DR11

Pernicious anaemia

HLA DR5

subacute thyroiditis

HLA B35

linkage equilibrium in nephrotic syndrome

HLA A1, B8, DR3

acquired immunodeficiency syndrome

HLA A1, B8, DR3

post partum thyroiditis

HLA DR4

pemphigus vulgaris (among Ashkenazi jews)

HLA DR4

psoriasis vulgaris

HLA-Cw6