Flashcards in Autoimmunity Deck (27):
What is rheumatoid arthritis?
-an autoimmune mediated inflammatory arthritis that leads to destruction of cartilage and bone
-systemic progressive inflammatory disorder
What diseases are associated with rheumatoid arthritis?
**shortened life expectancies
Mutations in genes for which MHC class is associated with rheumatoid arthritis?
MHC Class II
What is the Pannus?
-Inflammatory region in RA
-the area where the synovial membrane meets the bone
-in rheumatoid arthritis, this is where inflammed synovial membrane activates osteoclasts via cytokines
-leads to destruction of the joint
What is Rheumatoid Factor?
-antibody against Fc region of IgG
-85% of patients have RF
-It is not specific for RA - seen in other autoimmune diseases, chronic infections, elderly, and 10% of healthy individuals
What are Anti-cyclic citrullinated peptides (aCCP)?
-present in about 65-70% of RA patients
=loook this up
What inflammatory cytokines are implicated in causing rheumatoid arthritis?
What hormone is associated with an increased risk for lupus?
What tend to be the targets for antibodies in Lupus?
(DNA and RNA complexes)
How many of the 11 ACR diagnostic criteria must be present to make a diagnosis of Lupus?
What is malar rash?
-ACR criteria for Lupus
Flat or raised,
Over the malar eminences
Spares the nasolabial folds
What is Discoid Lupus?
-ACR criteria for lupus
-Erythematous raised patches with adherent keratotic scaling and follicular plugging;
Atrophic scarring in older lesions
How is arthritis resulting from Lupus different from arthritis caused by rheumatoid arthritis and other autoimmune arthriti?
-Arthritis with lupus is non-erosive, and thus reversible
What is the primary target of Polymyositis?
What is the primary target of Dermatomysitis?
Muscle & Skin
What is the primary target of Systemic sclerosis/Scleroderma?
What is the primary target of Sjogrens Syndrome?
Salivary and lacrimal glands
What is scleroderma?
-Multisystem disease characterized by fibrosis of the skin and internal organs
-Vasculopathy : widespread functional and structural abnormalities in small arteries, arterioles, and capillaries
What is Systemic Sclerosis?
-Subset of scleroderma
-Puffy skin progressing to skin tightening and fibrosis
-Internal organ involvement
What is Raynaud's Phenomenon?
-Closure of muscular digital vessels
-Triggered by cold or stress, exacerbated by medications (beta-blockers)
-Triphasic color changes (pallor, cyanosis, erythematous)
-Seen in 4-15% of normal population
-Seen in 95% of patients with scleroderma
What is the clinical presentation of Polymyositis?
-Insidious onset of proximal muscle weakness in shoulder and pelvic girdles
-50% of pts have weakness in neck flexors
What is the clinical presentation of Dermatomyositis?
-Proximal muscle weakness and associated symptoms similar to polymyositis
What immune cells are associated with Polymyositis?
What immune cells are associated with Dermatomyositis?
*also Complement & antibodies
What is Sjögren’s Syndrome?
-lymphocytic infiltration of exocrine glands
(salivary and lacrimal)
-also has systemic manifestations
25% have internal organ involvement
Tell me about Scleroderma Renal Crisis.
-its an emergency
-Involves accelerated hypertension and rapid renal failure
-ACE inhibitors will save the patient's life