Autonomic Nervous System-PNS Flashcards
(118 cards)
1
Q
Choline reuptake inhibitor
A
Hemicholinum
2
Q
Prevent entry of acetylcholine into vesicle inside the presynaptic neuron
A
Vesamicol
3
Q
Antibiotics which block Ca+2 channel leading to blockage of Ach release on presynaptic neuron causing neuromuscular toxicity and worsening of myasthenia gravis
A
Aminoglycosides
4
Q
If neuromuscular toxicity caused by Aminoglycosides then treatment method is
A
Calcium
5
Q
Which two drugs directly block the release of Acetylcholine from presynaptic neuron
A
Beta-Bungarotoxin
Botulinum toxin
6
Q
M1 agonist used in the treatment of Alzheimer’s disease
A
Taclifensin
7
Q
Whose venom causes release of Ach
A
Spider
8
Q
A nonselective muscarinic agonist used to treat xerostomia and glaucoma
A
Pilocarpine
9
Q
Since Nm and Nn receptors are different which drug blocks the Nm receptors?
A
Tubocurarine and Atracurium
10
Q
Name two drugs are used to block the Nn receptors?
A
Hexamethonium and Mecylamaine
11
Q
Indirect acting anti-cholinergic examples (3)
A
Aminoglycosides
Beta-Bungarotoxin
Botulinum toxin
12
Q
Direct acting cholinergic drug used in atonic bladder
A
Bethanechol
13
Q
Direct acting cholinergic drug used in tachyarrythmia which acts on myocardium
A
Methacholine
14
Q
Direct acting cholinergic drug used for closed angle glaucoma acting on pupil
A
Pilocarpine
15
Q
Directly acting cholinergic drug used in Sicca or Sjorgen syndrome and xerostomia which acts on gland secretion
A
Cevimeline
16
Q
Drug of choice in closed angle glaucoma is
A
Pilocarpine
17
Q
4 examples of miotic agents
A
Pilocarpine
Physostigmine
Echothiphate
Fluostigmine
18
Q
Which drugs used as miotic agents and are also ACHE inhibitors which have a side effect of forming cataract while pilocarpine doesn’t ?
A
Physostigmine
Echothiphate
Fluostigmine
19
Q
Which type of drugs have common side effects such as accommodation spasm, brow ache, retinal detachment
A
Miotic agents
(Due to increase Ca level in muscles of accomadation)
20
Q
Which drug is used as topical mitotic agent in ocular surgery
A
Acetylcholine
21
Q
Shortest acting beta blocker metabolised by pseusocholinestrase
A
Esmolol
22
Q
Shortest acting muscle relaxant metabolised by psuedocholinstrase
A
Succinyl Choline
23
Q
Shortest acting opoids which are metabolised by psuedocholinesterase
A
Remifentanil
24
Q
Shortest acting calcium channel blocker which are metabolised by pseudocholinesterase
A
Clevidipine
25
Which type of drugs are used to treat smoke dependence
Nicotinic agonists
26
Types of Muscuranic agonists which are Amines or Alkaloids
Pilocarpine
Cevimeline
27
Type of Muscuranic agonists which are Choline esters
Acetylcholine
Methacholine
Bethanechol
Carbachol
28
3 drugs of direct acting nicotinic agonists
Nicotine
Varenicline
Cytisine
29
Which is a more effective drug than pilocarpine used in xerostomia
Cevimeline
30
Which drug is first line drug in an acute attack of closed angle glaucoma
IV Mannitol
31
Which drug is used to maintain normal IOP which is first decreased by IV Mannitol in case of acute attacke of closed angle glaucoma
Pilocarpine
32
Acetylcholine derivatives resistant to both ACHE and psuedocholinesterase
Bethanechol
Carbachol
Methacholine
33
Which drug is used as mitotic agent in ocular surgery and closed angle glaucoma
Carbachol
34
Which drug is used in bronchial challenge test to diagnose bronchial asthma as it is short acting
Methacholine
35
Which drug is used in gastroparesis and postoperative paralytic ileus
Bethanechol
36
A direct acting cholinergic muscuranic agonists which acts majorly on M2 receptor
Methacholine
37
A direct acting muscuranic agonists and a choline ester is used because it acts on M3 receptor
Methacholine
38
Irreversible indirect acting cholinergics
Organophosphates
39
Reversible direct acting cholinergics
Carbamates
40
Which drugs are ACHE activator which break phosphate bond of OPC which have not gone through ageing and have free anionic site
Oximes
41
Drug of choice in cholinergic poisioning
Atropine
42
OPC drugs used in warfare agents (5)
Nerve gas such as
Sarin
Cyclotron
Tabun
Vc
Soman
DPF
43
Which indirect acting cholinergic drugs are OPC used clinically (2)
Echothiophate
Fluostigmine
44
Which OPC form commonly causes cholinergic poisoning
Insecticides and Pesticides
45
Which four drug form poisoning have common symptom of pinpoint pupil?
Opoid poisoning
Cholinergic poisoning (eg OP and Carbamate)
Phenol poisoning
Pontine Haemorrhage
Early Mushroom poisoning
46
Which drug form is more specific for OPC poisoning?
Oximes
47
Since atropine has only anti-muscuranic action so which drug form is used to relieve the nicotinic symptoms in cholinergic poisoning?
Oximes
48
3 examples of oximes used in OPC poisoning
Pralidoxime
Obidoxime
Diacetyl mono oxime
49
Which form of oxime is commonly used in India?
Pralidoxime
50
Example of carbamates which are tertiary amines and can cross BBB
Physostigmine
Rivastigmine
51
Tertiary Amines which are non-carbamates and can cross BBB
Galantamine
Tacrine
Donepezil
52
Which drug is derived from calabar beans of planta physostigma venenosum
Physostigmine
53
Which drug is drug of choice for anti-cholinergic poisoning
Physostigmine
54
Which drug is used in treatment of closed angle glaucoma
Physostigmine
55
3 types of anticholinergic poisoning
Atropine toxicity
Belladonna toxicity
Datura toxicity
56
Which 4 drugs are used for treatment of Alzheimer's disease since they are highly lipid soluble and majorly cross BBB without causing peripheral side effects
Rivastigmine
Galantamine
Tacrine
Donepezil
57
Which is drug of choice for Alzheimer's disease
Donepezil
58
Drug form used in Myasthenia Gravis which block ACHE to increase ACh since it doesn't cross BBB and act on periphery such as muscle
Quartenary Amines
59
Which drug is short acting and used in diagnosis of MG (Tensilon test)
Edrophonium
60
Which drug is used to differentiate MG and Cholinergic crisis
Edrophonium
1: improves
2: worsens
61
Which drug is used in paroxysmal supraventricular tachycardia (PSVT) as it blocks AV node
Edrophonium
62
Which drug is used in diagnosis and treatment if pyridostigmine is not present
Neostigmine
63
Premedication with which drug is required while using edrophonium and neostigmine to avoid muscuranic side-effects?
Atropine
64
Which drug us used in non-depolarizing muscle relaxant seen with atracurium, pancuronium
Neostigmine
65
Which drug is used in Cobra bites since Cobra toxin damages NMJ causing respiratory paralysis
Neostigmine
66
Which is drug of choice in generalised MG
It is oral and longer acting
Pyridostigmine
67
Which drug form is given in pyridostigmine resistant patients
Steroids
68
4 example of Immunosupressants given in patients of MG resistant to pyridostigmine and steroids
Mycophenolate Mofetil
Cyclosporine
Rituximab
Azathioprine
69
Which is drug of choice in Myastheniac Crisis
Intravenous immunoglobulin (IVIG)
70
Which is alternate treatment modality for Myasthenic Crisis
Plasmapheresis
71
Which drug used to be a Drug of Choice for Alzheimer's disease until we found alternative since it was hepatotoxic and short acting
Tacrine
72
Which drug cannot be used for Alzheimer's disease since it's distribution in brain and periphery is 50% which is not effective even after crossing BBB?
Physostigmine
73
Which drug is used in post-operative paralytic ileus and post-operative urinary retention which acts on M3 receptors?
Neostigmine
74
Example of OPC drugs
Malathion
Parathion
Nerve gases forms
75
Which drug cannot be given to overcome carbamate poisoning since carbamate form bond with both esteratic and anionic site
Oximes
76
Which drug is used in Lambert Eaton syndrome as it blocks K+ channel which increase Ach release and increase muscle strength
Aminopyridines
77
Drugs used for treatment of MG
Ambemonium
Neostigmine
Pyridostigmine
78
Which anti-cholinergic drug which is a NM blocker is used for Tourette's Syndrome?
Mecamylamaine
79
Which drug is usd adjunct to nicotine in smoking depenede?
Mecamhlamaine
80
Which anti-cholinergic drug used in hypertensive emergency intra-venously?
Trimethapan
81
Which drug is used as K channel blockers for experiments
Tetraethylammoniun
82
Which drug is known as the truth serum ?
Scopolamine
83
Which drug is drug of choice in Narcoanalysis?
Thiopentone
84
Which is the preffered cycloplegic in adults and is also shortest acting
Tropacamide
85
Which drug is preffered cycloplegic in children
Atropine
86
Which drug is an add on drug in fungal corneal ulcer
Atropine
87
Drugs used in pupil which are muscuranic antagonists?
Tropacamide
Atropine
Cyclopentolate
Homatropine
88
Which anti-cholinergic drug is a muscuranic antagonist, reduce secretions, is a preferred preanesthetic medication, doesn't cross BBB and is a quartenary amine
Glycopyrrolate
89
Drugs used to reduce oropharyngeal secretions?
Atropine
Glycopyrrolate
90
Which drugs are DOC in COPD and add on drugs in bronchial asthma
These are muscuranic antagonists acting on lungs
Ipratropium
Oxitropium
Aclidinium
Glycopyrrolate
Umeclidinium
Revefenacin
Tiotropium
91
Which drug is given with nebulizer in acute exacerbation of bronchial asthma
Ipratropium
92
Which drug is drug of choice in COPD
LAMA which is Tiotropium
93
Which drugs forms to be avoided in patients of BPH?
Muscuranic antagonists used in bladder
94
Which drug is used in treatment of conduction blocks and digoxin toxicity
Atropine
95
Which drug is drug of choice for bradycardia
Atropine
96
At low doses which drug increase Ach which stimulate M2 receptors to causes further bradycardia
Atropine
97
Name two drugs which are M1 blockers? And used in peptic ulcer syndrome
Pirenzepine
Telemzepine
98
Which 3 drugs are anti-spasmodic?
Dicylomine
Glycopyrrolate
Scopolamine
99
Which drug is drug of choice for motion sickness
(It is only for Prevention and not the Treatment)
Scopolamine
100
Nonselective drugs which reduce detrusor contraction
Flavoxate
Oxybutynin
Fesoterodine
Trospium
101
Which drug used in overactive bladder doesn't cross BBB and is quaternary amine and not given to patients with renal failure as it is not excreted by liver
Trospium
102
Name the selective M3 blocker used in bladder
Darifenavin
Solfenacin
Tolterodine
103
A drug which is drug of choice for bradycardia and AV block
Atropine
104
A drug which causes transient bradycardia since it blocks first pre-synaptic receptors but later blocks post-synaptic receptors which are M2 on heart leading to final result as tachycardia
Atropine
105
Which drug is not given in cause of lungs and bronchus issue because it can't be given through inhalation route and inhibits mucociliary clearance
Atropine
106
A trick for drugs which are muscarinic antagonists used in overactive bladder etc.
(SOFT Bladder)
Solifenacin
Oxybutynin
Flavoxate
Fesoterodine
Tolterodine
Trospium
Darufenacin
107
Which two drug are most vesico-selective (most block M3 receptor)
Solefenacin
Darifenacin
108
Anti-cholinergics are drug of choice for Drug-induced Parkinsonism like
Benzhexol
Benztropine
Procyclidine
109
Which drug is used for early mushroom poisoning caused by inocybe
Atropine
110
Drug of choice for Belladonna and Datura poisoning is
Physostigmine
111
Which drug is contradicted in Late mushroom poisoning caused by Amanita species
Atropine
112
Which drug is used as an anti-spasmodic to reduce activity of GI tract
Atropine
113
Which drug is used to measure refractive error without interference of accomodation capacity of eye
Atropine
114
Which drug is preferred for pupillary dilation if cycloplegia is not required
Phenylephrine
(Alpha-adrenergic)
115
Which 3 drugs are mainstay of medical therapy for OP poisoning
Atropine, Pralidoxime and benzodiazepines
116
Which drug is used to treat poisoning with quartenary antimuscuranic poisoning
Neostigmine
117
Which drug is used to treat post operative nausea and vomiting
Scopolamine
118
Which type of drugs are used in nicotinic poisoning
Ganglionic Blockers
