Endocrine System

Question 1

Na/I symporter Inhibitors

Answer 1

Thiocyanate
Fluoroborate
Perchlorate

Question 2

Drugs under Thioamide which block Thyroxine Peroxidase

Answer 2

Propylthiouracil
Methimazole

Question 3

What is the drug of choice for hyperthyroidism/Grave’s disease?

Answer 3

Methimazole

Question 4

What is drug of choice for hyperthyroidism/Grave’s disease in PREGNANCY?

Answer 4

Propylthiouracil

Question 5

What is drug of choice for hyperthyroidism/Grave’s disease in PREGNANCY?
1st trimester

Answer 5

Propylrhiouracil

Question 6

What is drug of choice for hyperthyroidism/Grave’s disease in PREGNANCY?
2nd and 3rd trimester

Answer 6

Methimazole

Question 7

What is drug of choice for hyperthyroidism/Grave’s disease in LACTATION?

Answer 7

Propylthiouracil

Question 8

What is drug of choice for Thyrotoxicosis/Thyroid Storm?

Answer 8

Propylthiouracil
Remeber to add in MOA

Question 9

What is drug of choice for SEVERE Thyrotoxicosis/Thyroid Storm?

Answer 9

Propanolol
(Avoid Arrythmia)

Question 10

Drugs which come under Iodides

Answer 10

Lugol’s iodide:5%
Potassium iodide:10%

Question 11

Iodide can be used for?

Answer 11

Thyroid Surgery
(Make it firm and small)
Nuclear Accidents
(As it blocks uptake of radioactive substance)
Thyroid Storm
(Given after methimazole)

Question 12

Drugs under 5’-deiodinases
(Blocks peripheral conversion of T4 to T3)

Answer 12

Amiadorone
Beta-Blockers
Steroids
Propylthiouracil

Question 13

Drugs under radioactive iodine

Answer 13

I 123
I 131

Question 14

Radioactive Iodine
I 131

Answer 14

Hyperthyroidism in cardiac and elderly
Toxic Nodular Goitre
Thyroid Cancer
Recurrent Grave’s

Question 15

What are the features of Levothyroxine

Answer 15

Less potent and Longer acting

Question 16

What is the drug of choice for replacement in hypothyroidism

Answer 16

Levothyroxine

Question 17

Features of T3/Leothyronine

Answer 17

More potent and shorter acting

Question 18

Uses of T4/Levothyroxine

Answer 18

IV Route:Myxedema Coma
Thyroid Cancers
(Reduce TSH)

Question 19

Uses of T3/Liothyronine

Answer 19

Myxedema Coma
I 131 Therapy

Question 20

Drug under Alpha glucosidase inhibitors

Answer 20

Acarbose
Voglibose
Miglitol

Question 21

Use of alpha glucosidase inhibitors

Answer 21

Type 2 DM

Question 22

Which is drug of choice for obesity

Answer 22

Liraglutide

Question 23

Drugs which are DPP4 inhibitors

Answer 23

SSavli (Gliptins)
Sita
Saxa
Alo
Vilda
Lina
Dape

Question 24

Amylin analogue name

Answer 24

Pramlintide

Question 25

Classification of insulin

Answer 25

Shortest and fastest acting: Afrezza Insulin Short acting Fast: Glusine, Lispro, Aspart Slow: Regular Insulin Intermediate acting: Isophane Insulin/Neutral protamine hagedorn (NPH) Lente Insulin Long acting: Glargine Detemir Degludec

Question 26

What is drug of choice for diabetic ketoacidosis

Answer 26

IV regular insulin

Question 27

OHA which increase insulin release

Answer 27

Sulfonylureas Glinides

Question 28

Names of drug under sulfonylurease 2nd generation

Answer 28

Glibenclamide Glyburide Glipizide Glimepiride

Question 29

Drugs under glinides

Answer 29

Megaglitinides Repaglinides Phenylalanine analogue Nateglinides

Question 30

Sulfonylureas 1st generation drugs

Answer 30

Acetohexamide Tolbutamide Chlorpropamide

Question 31

Features of 2nd generation sulfonylureas (4)

Answer 31

Glyburide or Glibenclamide : It has an active metabolite. The drug gets concentrated in the ẞ islet cells and thus is longer acting than its half-life (T). OD dosing is sufficient. Glimepiride: Sulfonylurea with least dose requirement to induce hypoglycemia. Gliclazide: It has an additional antiaggregant effect. Glipizide: short acting. Lesser risk of hypoglycemia, hence preferred in elderly patients.

Question 32

Which guanide was banned ?

Answer 32

Phenformin due to severe lactic acidosis

Question 33

Drug of choice for treatment of DM 2

Answer 33

Metformin

Question 34

Drug of choice for ptophylaxis in pre-diabetics

Answer 34

Metformin

Question 35

Which drug is banned in USA and comes with black box warning in India

Answer 35

Piloglitazone

Question 36

SGLT 2 inhibitors Glifozin

Answer 36

Cana Dapa Empa Ertu

Question 37

Group of Drug of choice for Secretory Diarrhea

Answer 37

Somatostatin Analogues

Question 38

Drug group of choice in Tumors like Glucagonoma • VIPoma • GRFoma. • Somatostatinoma

Answer 38

Somatostatin Analoguee

Question 39

Drug of choice in variceal bleeding

Answer 39

Terlipressin

Question 40

Features of Somatostatin Location

Answer 40

LOCATION: Intestine, Stomach, Pancreas, Hypothalamus 2.INHIBIT: Gastrin Insulin Glucagon Growth Hormone

Question 41

Gonadotropins names 1.hMG 2. FSH 3.LH

Answer 41

MENOTROPIN Urofollitropin Folliotropin a &B. HCG Choriogonadotropin alpha

Question 42

Which androgen anatagonist aling with goserelin depot is used for prostate carcinoma

Answer 42

Bicalutamide

Question 43

GNRH agonists and analogues

Answer 43

Gonadorelin Leuprolide Goserelin Nafarelin Buserelin Triptorelin

Question 44

GNRH antagonists

Answer 44

Cetorelix Ganirelix Elagolix Abarelix

Question 45

Which should be always given along estrogen to reduce risk of endometrial carcinoma

Answer 45

Progestogen

Question 46

In which condition can estrogen be used alone

Answer 46

Hysterectomy

Question 47

HT have substantially less estrogen than contraceptipn

Answer 47

True

Question 48

Which drug is a 19-nonsteroid used for HRT and its metabolite have estrogenic, progestrogenic and androgenic properties

Answer 48

Tibolone

Question 49

Most potent bisphpsphanates

Answer 49

Zoledronate

Question 50

Which drug is drug of choice for osteoporosis

Answer 50

Bisphosphonates

Question 51

Which drug is drug of choice for hypercalcemia of malignancy

Answer 51

Bisphosphonates

Question 52

Which drug is drug of choice for pagets' disease

Answer 52

Bisphosphonates