autonomic receptors Flashcards Preview

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Flashcards in autonomic receptors Deck (33)
1

α1

VSM - vasoconstriction

GI/GU - constriction

Eye - mydriasis, aka dilation (constriction of pupillary dilator muscle!)

[theme = constriction]

2

α2

nerve terminals -> decr. NT release

platelets - increase aggregation

3

ß1

heart - increase HR, contractility

kidneys - increase renin release

[ß1: ONE heart ONE love to get your HR up]

4

ß2

lungs - bronchodilation [ß2: TWO lungs]

VSM - vasodilation

Uterus - relaxation (tocolysis)

[ex: Terbutaline: ß2 agonist relaxes uterine contractions -> stops premature labor]

5

D1

renal, splanchnic, and mesenteric BV smooth muscles -> vasodilation (increases renal + splanchnic blood flow)

[Incr RBF]

D for dilation

6

D2

nerve terminals & nT release in CNS

7

V1

VSM = increase contraction

ex: vasopressin

8

V2

renal CD - increase H2O uptake

[V2: 2 kidneys]

9

M1

CNS

enteric NS

10

M2

heart - decrease HR/contractility

[opposes ß1 effects]

11

M3

GI - increase peristalsis

GU - increase bladder contraction

lungs - bronchoconstriction

eyes - pupil sphincter

[M3 -> messy: tears, urine, sputum. H1 makes more mucous though]

12

H1

increase mucous production in nose, bronchus

increase vascular permeability

increase contraction of bronchioles

pain

[H1 blocker = antihistamines like diphenhydramine/Benadryl or Loratidine]

13

H2

increase gastric acid production

[H2 blocker: symetidine]

14

pupils - constrict

M3 (or α1 blockade)

15

pupils - dilate (mydriasis)

α1 (or M3 blockade)

16

VSM - dilate

ß2 (redirect flow towards specific areas during sympathetic activation)

17

VSM - constrict

α1, V1 (redirect flow away from specific aways during sympathetic activation)

18

heart - decrease HR/contractility

M2

19

heart - increase HR/contractility

ß1

20

lungs - bronchoconstriction

M3

21

lungs - bronchodilation

ß2

22

GI - increase peristalsis

M3

23

GI - decrease peristalsis

α1

24

GU - increase function

M3

25

GU - decrease function

α1

26

uterus relaxation

ß2

27

which receptor types use the Gq pathway? very generally what does this lead to?

H1, α1, V1, M1, M3 "HAVe 1 M&M."

or "HAVe 1,3 Chocolate M&Ms" since pathway uses Phospholipase C, Protein Kinase C, increases Ca, and uses IP3

-->leads to smooth muscle contraction

28

which receptor types use the Gs pathway? generally leads to what?

ß1, ß2, D1, H2, V2

pathway uses Adenylyl Cyclase, ATP, cAMP, PKA.

--> increases intracellular Ca in heart

29

which receptor types use the Gi pathway? generally leads to what?

M2, α2, D2

"MAD 2s"

these BLOCK the pathway that uses Adenylyl Cyclase, ATP, cAMP, PKA.

--> relaxes smooth muscle

30

effect of understimulating α1?

orthostatic hypotension

31

effect of understimulating α2?

Release of norepinephrine

Release of insulin

32

effect of understimulating ß1?

bradycardia

decr contractility, slower conduction

33

effect of understimulating ß2?

vasoconstriction

bronchoconstriction