B Cell maturation

Question 0

( With regards to TdT and B220) Intermediate Pro-B cells express:

Answer 0

TdT and B220

Question 1

( With regards to TdT and B220) Early Pro-B cells express:

Answer 1

TdT alone

Question 2

(With regards to TdT and B220) Late pro-B cells express:

Answer 2

B220 and downregulated TdT

Question 3

What is the purpose of B220?

Answer 3

Receptor for cell growth and differentiation

Question 4

At what point do B cells start to produce CD43 (leukosialin), CD19, RAG-1 and RAG-2.

Answer 4

Pro-B

Question 5

What is CD19?

Answer 5

BCR Coreceptor

Question 6

As B cells change from pro-B to pre-B, they downregulate…

Answer 6

TdT, RAG 1 and 2, CD43

Question 7

What induces Pro-B to turn into Pre-B cells?

Answer 7

c-Kit

Question 8

What stimulates pre-B cells to differentiate and proliferate?

Answer 8

IL-7

Question 9

At what stage is the light chain produced?

Answer 9

Immature B cell

Question 10

What is the cytokine that is important for survival of pre-immune B cells from transition stage onward?

Answer 10

Blys

Question 11

What are the three cytokines important for B cell differentiation?

Answer 11

IL-3, IL-4, L-BCGF

Question 12

Immunodeficiency XLA is the result of a defect in what kind of protein?

Answer 12

Bruton’s tyrosine kinase

Question 13

Does positive or negative selection come first in B cell transition?

Answer 13

Negative first, then positive

Question 14

What type of B cell will become plasma or memory cells?

Answer 14

Follicular B cells

Question 15

What type of B cells respond to T cell dependent antigens?

Answer 15

B-1 B cells

Question 16

B-1 cells never start to make…

Answer 16

IgG

Question 17

An antigen that activates both T and B cells is called a…

Answer 17

TD antigen: T dependent Antigen

Question 18

An antigen that activates only B cells is called a…

Answer 18

TI antigen: T independent antigen

Question 19

What type of antibodies are produced in a TI type 1 antigenic response?

Answer 19

IgM

Question 20

What receptors does lipopolysaccharide (a TIA type 1) bind on a B cell?

Answer 20

BCR and TLR4

Question 21

Type 2 TI antigens usually bind several ______ at once.

Answer 21

BCR’s