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IHO Week 4 > Lymphoma: Krafts > Flashcards

Lymphoma: Krafts Flashcards

0
Q

In a lymph node, where do B cells reside? T cells?

A

B cells: Follicles

T cells: Intergerminal centers

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1
Q

Most overall common cause of lymphadenopathy:

A

Benign reaction to infection

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2
Q

What are the cells that clear debris from normal lymph nodes?

A

Tingible body macrophage

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3
Q

If you biopsy a lymph node and find large, irregular follicles with varied cells and tingible bodies, what is the diagnosis?

A

Benign Follicular Hyperplasia

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4
Q

What is meant by partial effacement and what does it indicate?

A

Node is not completely replaced by the germinal centers.

If you can’t find germinal centers, likely malignant

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5
Q

What type of spreading pattern does Non-hodgkin’s lymphoma have?

A

Skips around

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6
Q

What do lymph nodes feel like in NH lymphoma?

A

Firm, but not rock hard

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7
Q

What are the B symptoms to lymphoma?

A

Night sweats, weight loss, fever

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8
Q

What is the cellular morphology of low grade NH lymphoma? High grade?

A

Low grade: Mature, small cells

High grade: Big, ugly cells

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9
Q

Small lymphocytic lymphoma is the same as…

A

Chronic lymphocytic leukemia

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10
Q

What cells and what unique genetic markers are present in SLL?

A

B cells with CD5+

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11
Q

What is the name of the transformation into large cells that makes mortality increase substantially from SLL?

A

Richter transformation

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12
Q

MALT lymphoma is a type of _______ lymphoma

A

Marginal zone

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13
Q

This bacterium is associated with marginal zone lymphoma

A

H. pylori

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14
Q

What does a marginal zone lymphoma lymphocyte look like in the blood?

A

More cytoplasm than usual

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15
Q

What cytogenetic abnormality is associated with Mantle Cell Lymphoma and what is the resulting protein problem?

A

t(11:14), Cyclin D1 overexpressed via IgH expression

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16
Q

Follicular lymphoma is graded via what characteristic?

A

Small cleaved cell, mixed, or large cell

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17
Q

What genetic abnormality leads to follicular lymphoma and what is the cellular manifestation?

A

t(14:18), bcl-2 increased by put next to IgH

18
Q

Butt cells are seen in…

A

Follicular lymphoma

19
Q

Paratrabecular aggregates are seen in…

A

Follicular lymphoma

20
Q

What is the lymphoma that presents as skin lesions?

A

Mycosis fungoides/Sezary syndrome

21
Q

What do cells look like with Mycosis fungoides/Sezary syndrome?

A

Cerebriform lymphocytes

22
Q

What cells are the problem under Mycosis fungoides?

A

T cells

23
Q

Diffuse large cell lymphoma involves what cells?

A

B cells

24
Q

Does diffuse large cell lymphoma have a good or bad prognosis?

A

Bad

25
Q

Lymphoblastic lymphoma is also known as

A

Acute lymphocytic leukemia

26
Q

How does lymphoblastic lymphoma present?

A

Teenage male with mediastinal mass

27
Q

What is the genetic abnormality of Burkitt’s lymphoma? What about the problem that results?

A

t(8,14), c-myc expressed at high levels due to being next to IgH

28
Q

What does Burkitt’s lymphoma look like on a patient?

A

Large, fast growing masses extranodally

29
Q

What cells do you see in a burkitt’s lymphoma cellular mass?

A

tingible bodied macrophages

30
Q

What is unique about how the CELLS look in Burkitt’s lymphoma?

A

Blue cytoplasm

31
Q

Where (geography) does Adult T Cell Lymphoma present?

A

Japan and caribbean

32
Q

What causes Human T cell lymphoma?

A

HTLV-1

33
Q

What are some common clinical findings in HTL?

A

skin lesions, hypercalcemia

34
Q

Hodgkin’s lymphoma has a unique cell called ______ that looks like _______.

A

Reed-Sternberg cell, owl eyes

35
Q

Who is at highest risk of getting Hodgkin’s lymphoma?

A

Young men and elderly

36
Q

How does Hodgkin’s lymphoma spread?

A

Pretty linearly

37
Q

What is the nature of the cells surrounding Reed-Sternberg cells?

A

Reactive. Not malignant

38
Q

What is a unique histological feature of Nodular L-P Hodgkin’s lymphoma?

A

Popcorn cells

39
Q

What is the usual presenting patient with Nodular L-P Hodgkin’s lymphoma?

A

Teenage male with cervical lymphadenopathy

40
Q

What is the prognosis for Nodular L-P Hodgkin’s lymphoma?

A

Good

41
Q

What is the most common subtype of Hodgkin’s lymphoma where you see lacunar cells?

A

Nodular sclerosis Hodgkin’s lymphoma

42
Q

Which Hodgkin’s lymphoma subtype has a poor prognosis and you see a mixture of background cells?

A

Mixed cellularity Hodgkin’s Lymphoma

43
Q

In this type of Hodgkin’s lymphoma, the background has collagen and reticulin.

A

Lymphocyte depletion HL

IHO Week 4 (11 decks)

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