Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

GIR Test 3 > B5-030 CBCL: Viral Hepatitis > Flashcards

B5-030 CBCL: Viral Hepatitis Flashcards

(88 cards)

Start Studying
1
Q

ssRNA picorna virus

A

HAV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

dsDNA hepadenovirus

A

HBV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

ssRNA flavivirus

A

HCV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

circular defective ssRNA deltavirus

A

HDV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

ssRNA hepevirus

A

HEV

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what hepatitis viruses have a vaccine available?

A

A and B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what hepatitis viruses are spread fecal-orally?

A

A and E

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what serology is used to diagnose Hep A?

A

IgM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what serology is used to diagnose Hep B?

A

HBsAg
HBcAg
PCR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what serology is used to diagnose Hep C?

A

HCAb
PCR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what serology is used to diagnose Hep D?

A

HDV IgM
PCR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what serology is used to diagnose Hep E?

A

HEV PCR, IgM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

which hepatitis viruses cause acute infection?

A

A and E

AcutE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what will be the biggest clinical distinguishing factor between Hepatitis A and E?

A

exposure risk

A: daycares
E: travel, unclean water, shellfish, etc.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

elevated liver transaminases into the 1000s indicates

A

Hep A/E

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

fulminant hepatic failure occurs in 20% of pregnancy cases

A

Hep E

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

whats a good way to differentiate the acute hepatic viruses causing hepatitis from CMV, EBV, etc.?

its a lab value

A

CMV/EBV usually only cause liver transaminases to rise into the 100s and usually have associated pharyngitis

HepA/E would cause AST/ALT into the 1000s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

first stage of liver scarring after portal tract inflammation

A

fibrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

HCV induces insulin resistance leading to […] which contributes to fibrosis

A

steatosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

when fibrosis takes over the whole liver, fibrous tissue encompases regenerating nodules causing a nodular appearance

A

cirrhosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

associated with aplastic anemia, glomerulonephritis, polyarteritis nodosa

A

Hep B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

associated with metabolic disorders, cryoglobulinemia, glomerulonephritis

A

Hep C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

combination therapies for Hep C

2

A
  • glecaprevir/pibrentasvir
  • sofosbuvir/velpatasvir

other based on genotype

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

first line treatment for Hep B

A

tenofovir, entecavir

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
who should be treated for Hep B?
* pregnant * active malignancy * HIV * immunosuppressed * liver failure related to Hep B * very high viral load
26
what is the mechanism of action for tenofovir, entecavir, and adefovir
reverse transcriptase inhibitor
27
what two antivirals are not preferred for Hep B due to increasing resistance?
adefovir lamivudine (cystosine analog)
28
who should be treated for Hep C?
everyone with HCV except those with short life expectancy due to liver failure
29
MOA for NS5A inhibitors | -asvir
inhibit NS5A which aids in RNA replication
30
side effects of NS5A inhibitors? | -asvir
headaches diarrhea
31
MOA of NS5B inhibitors? | -buvir
inhibit NS5B, RNA-dependent polymerase that acts as a chain terminator | prevents RNA replication
32
side effects of NS5B inhibitors? | -buvir
headache fatigue
33
MOA for NS3/4A inhibitors | -previr
inhibit NS3/4A protease preventing viral replication
34
side effects of grazoprevir | NS3/4A inhibitor
headache fatigue
35
side effects of simeprevir | NS3/4A inhibitor
photosensitvity rash
36
inhibits synthesis of gaunine nucelotides by competing with IMP dehydrogenase
ribavirin
37
side effects of ribavirin
anemia fatigue rash
38
if a patient has Hep C and diabetes, monitor for
hypoglycemia
39
if a patient has hep C and cirrhosis, monitor for | 2
HCC varices
40
treatment for Hep A?
supportive
41
which hepatic virus causes steatohepatitis?
hep C
42
the presence of [...] indicates the hepatitis B vaccine has been effective
anti-HBs
43
treatment for hep B? | 3
* highly concentrated Hep B IgG * INF-a * nucleotide analogs that inhibit viral replication
44
nucleotide analogs that inhibit viral replication | 4
* adefovir * telbivudine * entecavir * tenofovir
45
which hepatic viruses cause chronic infection?
B, C, D
46
what is the best test to determin active Hep B infection?
HBsAg detection
47
associated with a high mortality rate in pregnant women
Hep E
48
what is the most important goal of treatment in chronic HBV infection?
lose HBsAg from serum
49
is HCV IgG protective against reinfection?
no | replicates/changes to evade immune system
50
daycares are associated with an increased risk of
HAV
51
HAV IG is effective at preventing HAV in unvaccinated, exposed individuals if given within
2 weeks
52
ribavirin is used to treat
HCV
53
in the case of an HAV outbreak, what next step should be taken by the health department?
administer IG to all previously unvaccinated exposed individuals | can give vaccine at same time
54
if it is not feasible for a patient to receive both vaccines in the Hep A series prior to traveling to an endemic area, what is the best recommendation?
first dose 4 weeks before + IG
55
how is the hep A vaccine administered?
two shots 6-12 months apart
56
what serum markers would be elevated in the acute phase of an HBV infection?
HBeAg and HBsAg
57
approximately [...] of needle sticks result in HCV infection | %
5%
58
[...] % of HCV infections become chronic
70-80
59
major risk factor for development of cirrhosis in HCV infected patients
alcohol
60
normal alpha fetoprotein
less than 20
61
what laboratory test is useful for determining HCC?
a-fetoprotein
62
Anti-HBsAg + Anti-HBcAg + Anti-HBeAg+
previous HBV infection, now recovered
63
HBV in neonates and young children results in chronic infections [...]% of the time
90
64
large cytoplasmic inclusions that push the nucleaus to one side of the cell
ground glass hepatocytes (HBV)
65
considerations for treatment in HBV
* over 40 years of age * family hx of liver cancer * extrahepatic complications (vasculitis, renal disease)
66
nucleosides analogues that share cross-resistance
telbivudine lamivudine
67
the major drawback of INF-a therapy
flu-like side effects
68
what medication can cause the rare side effect of renal insufficiency?
tenofovir disproxil fumarate
69
should the same dose of entecavir be used for treatment-naive patients and lamivudine-resistant patients?
no, lamivudine resistant patients should receive a larger dose
70
how quickly after exposure should HBV ppx be administered?
ideally within 24 hours benefit shown up to 7 days
71
post-exposure PPX for HBV should include | 2
first dose of vaccine and HBIG
72
[..]% of healthcare workers have not completed the HBV series
25
73
without post-exposure ppx, what is the risk of contracting HBV from a needle stick? | %
5%
74
all pregnant women should be screened for HBV by screening serum for
HBsAg | prevents perinatal HBV transmission
75
preferred screening test to determine whether the mother is at risk of transmitting HBV to her child
HBsAg
76
a normal ALT does not exclude [...] in HBV-HIV coinfected patients
possibility of fibrosis
77
INF-a should be used with caution in patients with
cirrhosis increases risk of immune-modulated hepatic decompensation
78
has combination therapy with two or three antivirals been shown to improve outcomes over single therapy in patients with chronic HBV?
no
79
Anti-HCV positive indicates
HCV infection
80
does HCV have a vaccine?
no
81
has recently been reported to be transmitted zoonotically, through organ transplantation, or blood transfusions
HEV
82
occurs when Hep B is present and constant usage of alcohol damages the liver
Hep D
83
edema, weight gain, and ascites are signs of
cirrhosis
84
anti-HBs IgG+ likely indicates
vaccination against hep B
85
associated with recent travel history
Hep A
86
laboratory indicators of hepatitis | 2
* elevated transaminases * elevated serum bilirubin
87
recommended treatment for exposure to HBV in unvaccinated individuals
HBIG + HBV vaccine
88
treatment for acute hepatitis
adequate nutrition and rest

GIR Test 3 (16 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions