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Flashcards in Bacteria Deck (18):
1

Chlamydia

Obligate intracellular pathogen
Transmitted between cells as elementary bodies
Replicate in cells as reticulate bodies

2

Staphylococcus spp

Gram-positive cocci
S. aureus can colonise meat a room tissue
Causes GI disease via toxin but doesn't colonise epithelium

3

Streptococcus spp

Gram-positive cocci
S. pyogenes causes pharyngitis
Produces pore-forming toxins (streptolysins)
Later complications are rheumatic fever and glomerulonephritis
S. pneumoniae colonises nasopharynx
Migrates to lower respiratory tract and causes pneumonia

4

Neisseria spp

Gram-negative cocci
N. gonn

5

Corynebacterium spp

Gram-positive rods
C. diphtheria causes respiratory disease
Extensive inflammatory exudate and pseudomembrane in nasopharynx

6

Clostridium spp

Gram-positive rods
C. difficile causes GI disease, produces toxins & spores
Colonises following broad-spectrum antibiotics
Disrupts tight junctions via releasing toxins which glycosylate GTPases
Can form pseudomembranes

7

Escherichia spp

Gram-negative rods
E. coli - GI disease:
ETEC: colonise via adhesins
EPEC: forms pedestals
EHEC: forms pedestals, shigella-like toxin exacerbates inflammation, 0157 main serotype

8

Salmonella spp

Gram-negative rods
Invasive intracellular pathogen causes GI disease
Typhii, causes typhoid fever (replicates in macrophages)

9

Pseudomonas spp

Gram-negative rods
Aeruginosa: opportunistic bacteria
Form biofilms in lungs of cystic fibrosis patients (alginate polysaccharide)

10

Bacteroides spp

Gram-negative rods

11

Vibrio cholerae

Cholera, colonises intestinal epithelium
AB5 toxin

12

H. pylori

Spiral-shaped, gram -ve causing gastric/duodenal ulcers
Extremely motile
Secrete ureases

13

Bordetella pertussis

Whooping cough
Damage ciliated epithelium via LPS, pertussis toxin and adenylate cyclase

14

Yersinia pestis

Bubonic plague: point source from rodents
Pneumonic plague: propagated source from humans

15

Toxoid vaccines

Diphtheria, tetanus

16

Killed whole cell vaccines

Whooping cough (B. pertussis), cholera

17

Live attentuated vaccines

Typhoid (S. typhii), TB (M. bovis)

18

Purified polysaccharide vaccines

Pneumonia, meningitis (Neisseria)