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2 - BOD > Immunity > Flashcards

Flashcards in Immunity Deck (22):
1

IL-1

Activates NF𝜅B/AP1 (transcription factors)
Proinflammatory, endogenous pyrogen

2

IL-6

Pro-inflammatory, acute phase protein response, endogenous pyrogen

3

IL-12

Stimulates T/NK cells
Increases IFNɣ/TNFα production, cytotoxicity and TH1 response

4

TNFα

Activates NF𝜅B/AP1 (transcription factors)
Acute phase protein response, endogenous pyrogen
Involved in spetic shock

5

CXCL8 (IL-8)

Chemokine: attracts neutrophils/other cells

6

Complement activation

Alternative: spontaneous - iC3Bb convertase
Lectin: MBL/MASP-1/2, MBL binds mannose, C4b2a formed by MASP-2 cleavage
Classical: C1 (C1q/r/s), C1q binds Fc/CRP, C4b2a formed by C1s cleavage

7

C3a/C5a

Anaphylatoxins: stimulate mast cell degranulation

8

C3b/C4b/C5b

Opsins: enhance phagocytosis

9

MAC

C3bBb + C3b → (C3b)(C3b)Bb cleaves C5 → C5b
C5b complexes with C6, C7, C8 which recruits C9 monomers to form MAC
MAC and perforin similar molecules
C3b opsonisation more important (except in some infections eg gonorrhoea and Neisseria meningitis)

10

Properdin

Stabilises C3bBb on microbial surfaces

11

Factor H

Binds C3b, recruits factor I which cleaves into iC3b

12

Decay accelerating factor

Causes Bb to dissociate from C3bBb

13

Membrane cofactor protein

Causes Bb to dissociate from C3bBb and recruits factor I

14

CD59

Binds assembling MAC and prevents C9 recruitment

15

MHC binding pocket

Class I: closed ends 8-9 a.a.
Class II: open ends 13-25 a.a.

16

TAP

Peptide pump found in MHC locus (allows co-regulation) which pumps peptides into the ER for MHC class I loading

17

Invariant chain

Binds MHC class II in ER to prevent self-peptides binding, cleaved in endosome to CLIP before being removed completely

18

CD40

Crosslinking stimulates isotype switching and B-cell activation without co-stimulation (and promotes survival)

19

Co-stimulation

CD40L (T-cell) - CD40 (APC)
CD28 (T-cell) - B7 (APC)
Results in IL-2 secretion: autocrine proliferative signal

20

TH1-response

Stimulated and produce IFNɣ/IL-12 (IL-12 secreted by macrophages)
Inhibited by IL-4 (macrophages by IL-10)
Proinflammatory, intracellular infections
Cellular response (macrophage activation etc)

21

TH2-response

Stimulated by IL-4 (from mast cells)
Production of IL-10 (inhibits macrophages), IL-4, 5, 13
Promotes humoral response and repair
Defence against helminths

22

TH17-response

Enhanced neutrophils, IL-17 (also activate fibroblasts/epithelial cells to secrete chemokines)