Viruses Flashcards Preview

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Flashcards in Viruses Deck (21):
1

IFNα/β

Released by infected cells
Stimulate antiviral state in neighbouring cells via JAK-STAT pathway
(ISGF binds ISRE - stimulates antiviral protein production)

2

Latency in herpesviruses

All herpesviruses can form latent infections
VZV: latent in sensory ganglia neurons
HCMV: monocytes (reactivate upon differentiation to macrophages)

3

Papovaviruses

dsDNA, icosahedral, no envelope
HPV 16/18 cause cervical carcinoma

4

Adenoviruses

dsDNA, icosahedral, no envelope
Adenoviruses causes acute respiratory disease

5

Herpesviruses

dsDNA, icosahedral, enveloped
HSV - cold sores/genital warts (1/2)
VZV - chicken pox and shingles
EBV - glandular fever and Burkitt lymphoma
HMCV
HHV8 - Kaposi's sarcoma

6

Poxviruses

dsDNA, complex capsid, enveloped
Variola virus - smallpox
Vaccinia virus - vaccine against smallpox
Replicated in the nucleus

7

Parvoviruses

ssDNA, icosahedral, no envelope
Blue tongue virus

8

Picornaviruses

+ve sense ssRNA, icosahedral, no envelope
Poliovirus - poliomyelitis
Hepatitis A - acute hepatitis
Rhinovirus - common cold
FMDV

9

Togaviruses

+ve sense ssRNA, icosahedral, enveloped
Rubella virus

10

Flaviviruses

+ve sense ssRNA, icosahedral, enveloped
Hepatitis C - (acute and) chronic hepatitis
Yellow fever - haemorrhagic fever (jaundice)

11

Coronaviruses

+ve sense ssRNA, helical, enveloped
SARS

12

Orthomyxoviruses

Segmented (8) -ve sense ssRNA, helical, enveloped
Influenza A virus

13

Paramyxoviruses

-ve sense ssRNA, helical, enveloped
Measles
Mumps

14

Rhabdoviruses

-ve sense ssRNA, helical, enveloped
Rabies

15

Filoviruses

-ve sense ssRNA, helical, enveloped
Ebola virus

16

Retroviruses

+ve sense ssRNA (DNA intermediate), 100nm capsid, enveloped
HIV - AIDS
FLV - leukaemia in cats
RSV - sarcoma in fowls

17

Hepadnaviruses

dsDNA (RNA intermediate), icosahedral, enveloped
Hepatitis B

18

Live attenuated vaccines

Yellow fever
MMR
Polio (Sabin)
VZV
Pseudorabies
Rinderpest
Hepatitis A

19

Live related virus vaccines

Variola
Marek's Disease

20

Dead (inactivated) vaccines

Hepatitis A
Polio (Salk)
Rabies
Hepatitis B
FMDV
Influenza
HPV

21

Passive 'vaccines' (immunisation)

Rabies (post exposure)
Hepatitis B (post exposure in neonates)