bartonella & rickettsiaceae 1 & 2 Flashcards by Dalilah Izumi

what cell type is bartonella facultative intracellular for?

endothelial cells and erythrocytes

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in what population does bartonella cause clinical disease in?

accidental host
reservoir host animals in poor health

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what media do you grow bartonella on?

blood-enriched media (like chocolate agar)
-slow growth

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what bartonella spp causes endocarditis, hepatitis and other clinical syndromes in dogs and in cats?

B. henselae

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what is the reservoir for B. henselae

felids

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what is the vector for B. henselae

cat flea

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what disease does bartonella henselae cause and in what reservoir

endocarditis in felids

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what is the primary disease caused by bartonella spp

endocarditis

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what bacteria cause these lesions?

bartonella

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how is bartonella diagnosed?

presumptive: clinical presentation + exposure to biting arthropods

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how to confirm bartonella diagnosis

culture
PCR
MALDI-TOF

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what is the treatment for bartonella

antimicrobials
-doxy, azithromycin, enrofloxacin

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how do you control and prevent bartonella

limit animal exposure to vectors

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what type of disease does rickettsiales cause?

arthropod-borne diseases

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are rickettsiales facultative intracellular or obligate intracellular?

obligate intracellular

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who are the accidental hosts for rickettsiales?

humans
-dead end

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what are the following rickettsiales spp caused by
rickettsioses
anaplasmoses
ehrlichioses
neorickettsioses

rickettsia spp
anaplasma spp
ehrlichia spp
neorickettsia spp

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what is reservoir host for rickettsiales?

ticks

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what do rickettsiaceae spp induce host cells to do and what do they do once inside

they induce host cells to phagocytize them and once inside they escape phagosome and grow in cytoplasm and/or nucleus

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where do rickettsiacaea invade and grow

in endothelial cells of small blood vessels > necrotizing vasculitis

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what is the causitive agent of Rocky Mountain spotted fever?

rickettsia rickettsia

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what are the primary mammalian reservoirs for rickettsia rickettsia

wild rodents and other small mammals

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what are the primary vectors for R. rickettsia

american dog tick
Rocky Mtn wood tick
*brown dog tick

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what are the disease patterns for R. rickettsia

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what bacteria causes this disease pattern?

R. rickettsia (RMSF)

what bacteria causes this?

R. rickettsia (RMSF)

what is the diagnosis for R. rickettsia

clinical presentation +exposure to RMSF serology PCR

what is the treatment for R. rickettsia

antibiotic, doxy *treatment should not be delayed

what are the target cells for anaplasmataceae

infect cells of hematopoietic origin

where do anaplasmatatceae grow and where do they multiply

-most species grow in leukocytes -multiply within membrane-bound structures called morulae

what anaplasma spp infect RBC of ruminants?

A. marginale

what anaplasma spp infects platelets primarily in canids?

A. platys

what anaplasma spp. primarily infects granulocytes of diverse mammals

A. phagocytophilum

what happens when cattle are infected with anaplasma marginale and survive?

survivors have chronic, lifelong, subclinical infections (carrier state)

diagnosis for A. marginale in cattle

presumptive: hematological findings -inclusion bodies, typically near margin of stained RBC definitive: PCR, serology

what is the most prevalent tick-borne disease of cattle and what is the causative agent?

bovine anaplasmosis A. marginale

at what age are cattle most affected by A. marginale

what are the different transmission routes for A. marginale?

what is the treatment for A. marginale

tetracyclines or imidocarb

what is the control/prevention methods for A. marginale

-eliminate ticks and blood feeding flies -disinfect tools -isolate infected animals

what is the causative agent for infectious canine cyclic thrombocytopenia?

A. playtus

what is the main presentation for infectious canine cyclic thrombocytopenia?

epistaxis

what is the main vector for A. platys

brown dog tick

how is A. platys diagnosed in ICCT

clinical signs; history of tick exposure -ID morulae in stained platelets 4dx snap PCR for confirmatory

treatment for A. platys in ICCT

doxycycline

how is A. phagocytophilum transmitted?

wild rodents- main mammalian reservoir blacklegged ticks- vectors

what are the common signs of canine granulocytic anaplasmosis?

lameness (polyarthritis)

what is the causative agent of canine granulocytic anaplasmosis?

A. phagocytophilum

what is the causative agent of equine granulocytic anaplasmosis?

A. phagocytophilum

clinical signs for equine granulocytic anaplasmosis

diagnosis for A. phagocytophilum

clinical signs, history of tick exposure, hematology -ID of morulae in stained neutrophils -4dx snap -IFA -PCR

treatment for A. phagocytophilum

tetracycline (e.g. doxy)

what is the causative agent for canine monocytes ehrlichiosis?

E. canis

what is the main vector for E. Canis

brown dog tick

what is the causative agent for canine granulocytic ehrlichiosis?

E. ewingii

what is the reservoir host for E. ewingii

white-tailed deer dogs and coyotes

what is the main vector for E. ewingii

lone star tick

what causes enamel ehrlichiosis in dogs

E. chaffeensis

what bacteria species causes this?

E. canis

disease patter for E. Canis

tropism for monocytes and macrophages

what is the acute CME for E. canis

what is the chronic CME for E. canis

what is the disease pattern for E. ewingii

tropism for granulocytes -CGE similar to acute CME but milder and more often associated with lameness

what is the most common disease patter for E. chaffeensis?

primarily infects monocytes

DX, TX, and prevention for ehrlicia in dogs

what bacteria are obligate intracellular symboitantos of flukes?

neorickettsia

what is the causative agent for salmon poisoning disease?

N. helminthoeca

what is the causative agent for Potomac horse fever?

N. risticii

what is the reservoir/vector of N. helminthoeca

fluke Nanophyetus salmincola

what is the life cycle of N. salmincola

what does N. hemointhocea in dogs primarily infect?

monocytes and macrophages

SPD N. helminthoca in dogs

diagnosis for N. helminthoeca in dogs

-clinical signs + access to raw fish harvested form endemic areas -ID fluke eggs in feces -ID morulae in macrophages and monocytes -definitive: serology, PCR, sequencing of microbe-specific genes

treatment for N. helminthoeca

parenteral doxy or oxytetraycline

what is the reservoir/vector for N. risticii

intestinal fluke

what is the life cycle for N. risticii?

N. risticii in horses

what is the diagnosis for N. ricsticii in horses

treatment and prevention for N. risticii

bartonella & rickettsiaceae 1 & 2 Flashcards

(79 cards)