Basics of Endotoxemia and Shock Flashcards Preview

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Flashcards in Basics of Endotoxemia and Shock Deck (15):
1

What body water fraction is hypovolemia

plasma (25% of ECF)

2

what body water fraction is dehydration

Interstitial fluid (75% of ECF

3

components of hypovolemic shock

decreased venous return, cardiac output, and tissue perfusion. this leads to tissue hypoxia and irreversible cell damage

4

classifications of shock

hypovolemic
cardiogenic
obstructive
distributive (sepsis)
cytotoxic

5

basics of fluid therapy for shock

restore volume, distribution and content

6

effects of lactic acidosis

myocardial depression
less responsiveness to catecholamines
cns effects

7

Who to not give the hypertonic saline to

severely dehydrated patients (only hypovolemics)

8

clinical signs of hypovolemia and hypotension

loss of BP
poor pulse
collapsed veins
poor venous fill
poor capillary fill
this will cause compensation by cold shock

9

the best way to improve tissue oxygenation is

restore circulating volume

10

indications for blood transfusions

>20-30% of blood is lost

11

What will fluids added do to PCV

witll drop it

12

C/S of early de-comp stages of shock

pallor/cyanosis, prolonged CRT, low BP

13

autoregulatory escape as a decomp mechanism in shock

complete circulatory collapse,
bradycard
no CRT
no pulse
stupor, coma

14

pathophysiology of septic shock

microvascular pooling- --> blood pooling --> shunting of blood --> endothelial damage --> thrombosis --> increased permeability --> edema

this is an apparent hypovolemia but the vessels and dilated and nonresponsive

15

Tx principles for septic shock

fluids
address cause - drain, devitalize tissue debridement, AM
anti-inflammatores - NSAIDs steroids, flunixin
anti-endotoxin therapy - polymixin B, plasma
prevent complications