BB Intro Flashcards
First line of Defense Immunity
Innate or Natural Immunity
Major players in Innate or Natural Immunity
Macrophages, Leukocytes, NK cells, complement alt pathway, cytokines
Acquired or Adaptive immunity major players
Lymphocytes (T & B cells), macrophages, antibodies, complement classic pathway
Cells responsable for production of antibodies
Activated B cells —> Plasma Cells
First antibody class produced by plasma cells
IgM. T cell stimulation can turn it to IgG
Most immunogenic blood group system
ABO (only major BGS)
Most immunogenic antigen outside of ABO and immunogenicity %
D , 50%
What percentage of proteins in the body are antibodies?
20%
Name the 5 different Immunoglobulin classes
IgA, IgD, IgE, IgG, IgM
Amino terminal regions in antibody structure
Fab
Carboxyl region of antibody structure
Fc
Fragment in antibody structure responsable for complement fixation
Fc region (carboxyl terminal/constant region)
Where does complement bing on IgG molecule? (CH?)
CH2
Where does macrophage bind on an IgG molecule? Ch?
CH3
IgG classes that are most likely to be clinically significant and why
IgG 1 and 3. Because they bind complement the best.
Which Ig type can cause immediate hypersensitivity?
IgE (allergic reactions)
What is T cell deficiency called
DiGeorge syndrome
What cell is missing in Burton’s Agammaglobulinemia?
Absence of mature B cells
First response antibody timing and type
3-21 days. IgM (then it turns into IgG)
Secondary response antibody timing and type
Also called anemnestic response. Faster IgG on second exposure. Curve goes up faster and a lot higher
Portion of the complement cascade that binds to heavy chain
C1q binds to CH2 (complement attachment site)
Complement pathway members that cause anaphylaxis
C4a , C3a , C5a ( the ones ending in a)
Complement pathway members that form MAC
C5b C6 C7 C8 C9 form membrane attack complex MAC
Probability of finding units formula
Number of units divided by the product of the negative frequencies (x100). Always round up
