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MLS Classes > BB U5 Terms > Flashcards

BB U5 Terms Flashcards

1
Q

Endogenous sources

A

intracellular, shipping internal proteins – ANCs

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2
Q

Exogenous sources

A

extracellular, anything that is not you – B lymphs and APCs

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3
Q

Autologous

A

self donation

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4
Q

Syngeneic

A

twin donation

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5
Q

Allogeneic

A

other person donation

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6
Q

Xenogeneic

A

different species donation

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7
Q

GvHD

A

host system no longer exists and the WBCs in the graft grows to kill everything in host

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8
Q

HvGD

A

host kills the graft and therefore the host needs a replacement graft

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9
Q

T cell mediated

A

CD8 cytotoxicity against organ cells with different proteins on cells surface

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10
Q

Antibody mediated

A

B cell recognition and antibody production against foreign antigens

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11
Q

NK cell mediated

A

MHC I allorecognition with KIR facilities cytotoxic effects on foreign tissue

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12
Q

Hyper acute

A

pre-existing antibodies, minutes to days

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13
Q

Acute

A

CD4 and CD8 mediated, 1-2 weeks

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14
Q

Chronic

A

CD4 and B cell responses, 3 mth – 10 yrs

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15
Q

Hydros fetalis

A

edema in fetus/neonates

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16
Q

Icterus gravis

A

jaundice

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17
Q

Erythroblastosis fetalis

A

immature RBCs in circulation

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18
Q

Placental

A

a barrier between fetus and mother’s circulation, exchanges O2, nutrients, waste products

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19
Q

Kernicterus

A

accumulation of bilirubin in CNS

20
Q

Amniocentesis

A

bilirubin tested for ΔA450 on Liley graph

21
Q

Cordocentesis/PUBS

A

very invasive with 1-2% mortality rate, punctures near where umbilical cord enters the placenta

22
Q

DAT

A

diagnoses HDFN after birth

23
Q

Elution

A

removes antibodies from surface of RBCs

24
Q

Cord hemoglobin

A

indicates anemia and RBC

25
Q

Cord bilirubin

A

indicator for need of exchange transfusion and the presence of kernicterus

26
Q

Phototherapy

A

UV light breaks apart bilirubin

27
Q

Transfusion

A

small quantities of blood returns hemoglobin level to normal

28
Q

Exchange transfusion

A

reconstituted whole blood will be exchanged for infant’s circulated blood

29
Q

IVIG

A

treats hyperbilirubinemia

30
Q

RhoGAM

A

passive anti-D

31
Q

Candidate requirements for RhoGAM

A

Rh neg mom
Non-immunized (no sensitization to anti-D Rh neg mom
Rh neg moms with Rh pos babies
After invasive procedures like those who have miscarriages, abortions, ectopic, and amniocentesis

32
Q

Non-candidates include

A

Rh neg moms with Rh neg babies
Rh neg moms who already have a real anti-D
Rh pos moms

33
Q

Fetal screen

A

detects Rh pos

34
Q

Positive rosette

A

> 3 clumps per field

35
Q

Negative rosette

A

loose tumbleweed red cells

36
Q

Keilhauer-Betke Test (KB)

A

quantitates how many fetal cells (Hgb F) are in mom’s circulation

37
Q

Fetal hemoglobin

A

bright pink cells

38
Q

Mother/adult cells

A

light pink “ghost cells”

39
Q

Immune hemolytic anemia

A

shortens the RBC survival mediated by immune responses

40
Q

Alloimmune

A

immune system stimulated by foreign antigens made from corresponding hemolyzed antibodies, leads to transfusion reactions and hemolytic disease

41
Q

Autoimmune

A

can be warm or cold autoantibodies, where autoantibodies can be directed against their own antigen red cells

42
Q

Drug-induced

A

making antibodies to a particular drug or drug complex, but in turn, damages the patient’s red cells

43
Q

Warm autoadsorption

A

adsorbs out the antibody at 37 C using ZZAP or chloroquine diphosphate

44
Q

Drug adsorption mechanism

A

anti-drug antibody reacts to drug on RBC in vivo

45
Q

Immune complex

A

absorbed onto RBC surface

46
Q

Membrane modification

A

drugs alter RBC membrane and absorb all proteins in nonspecific manner

47
Q

Unknown mechanism/random

A

makes autoantibodies that recognize RBC antigens

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