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DERMATOPATHOLOGY > BENIGN AND MALIGNANT MELANOCYTIC TUMORS > Flashcards

BENIGN AND MALIGNANT MELANOCYTIC TUMORS Flashcards

1
Q

Usual ratio of melanocytes to keratinocytes

A

1:4 on the cheek
1:10 on the limbs

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2
Q

Melanocyte stains

A

(+) S100, Mart-1, HMB-45

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3
Q

How can you differentiate keratinocyte from melanocyte?

A

haloed nucleus WITHOUT cytoplasm = KERATINOCYTE

haloed nucleus WITH cytoplasm = MELANOCYTE

Ans
Keratinocyte
Keratinocyte
Melanocyte

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4
Q
A
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5
Q
A
  • if may nesting, you have to think of nevus or something bad
    *its difference from lentigo simplex is it has solar elastosis
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6
Q
A
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7
Q
A

Junctional Melanocytic Nevus

  • Nests of melanocytes are at the tips of rete ridges
  • starts and ends with a nest = BENIGN
  • no sun damage/ solar elastosis points to a benign lesion
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8
Q
A

Compound Melanocytic Nevus

Nests of melanocytes are found at the tips of rete ridges and in the dermis

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9
Q
A

Intradermal Melanocytic Nevus

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10
Q
  • Decrease in size of nest of melanocytes with depth
  • Decrease in size of melanocytes with depth
A
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11
Q

What are the congenital features of nevus

A
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12
Q
A
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13
Q
A
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14
Q
A

*focal lang na melanocyte migration sa epidermis. benign pa rin

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15
Q

Identify

A

KAMINO bodies - Degenerated and hyalinized melanocytic aggregates along the dermoepidermal junction

  • Can be composed of spindled cells, epithelioid cells or combination of both
  • There is maturation with depth: Dermal nests and melanocytes are smaller than those in the junctional component

Seen in spitz nevus

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16
Q
A
17
Q
A
18
Q
A
19
Q
A
20
Q
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21
Q
A

Common Blue Nevus

  • Fairly symmetric intradermal proliferation
22
Q
A
23
Q
A

*lentiginous spread - melanocytes are spread as single cells along the DEJ

24
Q

What does it mean by shouldering phenomenon?

A
25
Q

What are the features of dysplastic nevus?

A
26
Q

Features of Junctional melanocytic nevus

A
27
Q
A
28
Q

Characteristics of Melanocytes showing cytological atypia

A
29
Q
A
30
Q
A
31
Q
A

lentigo simplex

32
Q
A

Spitz nevus

33
Q
A

Blue nevus

34
Q
A

Melanoma

  • not symmetrical
  • not circumscribed (does not start and end with a nest)
  • melanocytes are atypical looking
  • no maturation (cells at the bottom are bigger that the cells above)
  • with solar elastosis
35
Q
A

DERMATOPATHOLOGY (16 decks)

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