BENIGN AND MALIGNANT MELANOCYTIC TUMORS

Question 1

Usual ratio of melanocytes to keratinocytes

Answer 1

1:4 on the cheek
1:10 on the limbs

Question 2

Melanocyte stains

Answer 2

(+) S100, Mart-1, HMB-45

Question 3

How can you differentiate keratinocyte from melanocyte?

Answer 3

haloed nucleus WITHOUT cytoplasm = KERATINOCYTE

haloed nucleus WITH cytoplasm = MELANOCYTE

Ans
Keratinocyte
Keratinocyte
Melanocyte

Question 4

Answer 4

Question 5

Answer 5

• if may nesting, you have to think of nevus or something bad
  *its difference from lentigo simplex is it has solar elastosis

Question 6

Question 7

Answer 7

Junctional Melanocytic Nevus

• Nests of melanocytes are at the tips of rete ridges
• starts and ends with a nest = BENIGN
• no sun damage/ solar elastosis points to a benign lesion

Question 8

Answer 8

Compound Melanocytic Nevus

Nests of melanocytes are found at the tips of rete ridges and in the dermis

Question 9

Answer 9

Intradermal Melanocytic Nevus

Question 10

• Decrease in size of nest of melanocytes with depth
• Decrease in size of melanocytes with depth

Answer 10

Question 11

What are the congenital features of nevus

Answer 11

Question 12

Question 13

Answer 13

Question 14

Answer 14

*focal lang na melanocyte migration sa epidermis. benign pa rin

Question 15

Identify

Answer 15

KAMINO bodies - Degenerated and hyalinized melanocytic aggregates along the dermoepidermal junction

• Can be composed of spindled cells, epithelioid cells or combination of both
• There is maturation with depth: Dermal nests and melanocytes are smaller than those in the junctional component

Seen in spitz nevus

Question 16

Question 17

Answer 17

Question 18

Answer 18

Question 19

Answer 19

Question 20

Answer 20

Question 21

Answer 21

Common Blue Nevus

• Fairly symmetric intradermal proliferation

Question 22

Question 23

Answer 23

*lentiginous spread - melanocytes are spread as single cells along the DEJ

Question 24

What does it mean by shouldering phenomenon?

Answer 24

Question 25

What are the features of dysplastic nevus?

Answer 25

Question 26

Features of Junctional melanocytic nevus

Answer 26

Question 27

Question 28

Characteristics of Melanocytes showing cytological atypia

Answer 28

Question 29

Answer 29

Question 30

Question 31

Answer 31

lentigo simplex

Question 32

Answer 32

Spitz nevus

Question 33

Answer 33

Blue nevus

Question 34

Answer 34

Melanoma - not symmetrical - not circumscribed (does not start and end with a nest) - melanocytes are atypical looking - no maturation (cells at the bottom are bigger that the cells above) - with solar elastosis