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DERMATOPATHOLOGY > FIBROSING & SCLEROSING DERMATITIS, COLLAGEN, ELASTIC, METABOLIC & PIGMENTARY DISORDERS > Flashcards

FIBROSING & SCLEROSING DERMATITIS, COLLAGEN, ELASTIC, METABOLIC & PIGMENTARY DISORDERS Flashcards

1
Q
A

Lichen Sclerosus et Atrophicus: Early lesion

  • Marked basal cell hydropic degeneration
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2
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Lichen Sclerosus et Atrophicus

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3
Q
A

Radiation Dermatitis

  • Hyperkeratosis and epidermal atrophy
  • Papillary dermal pallor without vacuolar change or lymphoid band
  • Large stellate radiation fibroblasts
  • Radiation elastosis
  • Loss of adnexa
  • Dilated ectatic vessels superficially
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4
Q

Differentiate lichen sclerosus and chronic radiation dermatitis

A
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5
Q
A

Morphea and Scleroderma

  • Early inflammatory stage: Superficial and deep lymphoplasmacytic infiltrate
  • Square/rectangular punch
  • Thick closely packed hyalinized collagen bundles in the lower dermis.
  • Loss of adventitial fat resulting in “trapped” eccrine glands
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6
Q

Conditions with Square Punch Biopsy

A
  • Morphea/Scleroderma
  • Scleredema
  • Chronic Graft vs Host Disease
  • Chronic Radiodermatitis
  • Connective Tissue Nevi
  • Scar
  • Normal skin of the back
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7
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8
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9
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A

Pseudoxanthoma Elasticum

  • Curled and frayed, calcified elastic fibers in the reticular dermis
  • Elastic tissue (Verhoeff–Van Gieson) and calcium (Von Kossa) stains highlight the distorted elastic fibers
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10
Q
A

Macular Amyloidosis

  • Sparse pink deposits in the papillary dermis
  • Amyloid is outlined by a fine network of melanophages
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11
Q
A

Lichen Amyloidosis

  • Hyperkeratosis and acanthosis
  • Pink amorphous deposits in the papillary dermis outlined by a network of melanophages
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12
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13
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14
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Calciphylaxis

  • Calcified and thrombosed vessels in the subcutaneous fat
  • Necrosis
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15
Q
A

Calciphylaxis

  • Calcified and thrombosed vessels in the subcutaneous fat
  • Necrosis
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16
Q
A

Ochronosis

  • Early lesion: markedly swollen collagen fibers
  • Developed lesion: Yellowbrown bodies in between collagen bundles in the dermis (Banana bodies)
17
Q
A

Scleredema

  • Thickened dermis
  • Widened spaces with mucin between normal collagen bundles
  • Mucin is most prominent in the deep dermis
  • No inflammatory infiltrate or increased fibroblasts
  • Features can be subtle with increased space between collagen fibers in the deep dermis
18
Q
A

Scleromyxedema

Increase in:
- dermal fibroblasts
- fine collagen fibers
- interstitial mucin

19
Q
A

Vitiligo

  • Active stage: Lymphocytic infiltrates
  • Absent melanocytes
  • Complete loss of melanin pigment from epidermis
20
Q
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Café au lait macules

  • Basal hyperpigmentation
  • No increase in melanocytes
  • Giant melanin granules
  • Disease associations:
  • Neurofibromatosis
  • McCune–Albright syndrome tuberous sclerosis
  • Fanconi anemia
  • Bloom syndrome
  • Russell–Silver syndrome
  • etc

DERMATOPATHOLOGY (16 decks)

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