NEURAL, FAT AND FIBROUS TUMOR

Question 1

Answer 1

NEUROFIBROMA

• Not encapsulated
• Spindle cells with elongated, sometimes wavy nuclei
• Mast cells
• S100 positive

Question 2

Answer 2

Neurofibroma

Question 3

Answer 3

Question 4

Answer 4

Question 5

Answer 5

Schwannoma

Answer 6

SMOOTH MUSCLE TUMOR: LEIOMYOMA

• Unencapsulated, intradermal tumor
• Interlacing and sometimes whorled bundles of smooth muscle cells
• Eosinophilic cytoplasm with blunt nuclear ends (cigar shaped)
• Special stain: Trichrome (red)
• IHC: Desmin

Question 7

Smooth muscle special stain

Answer 7

Trichrome Stain

Question 8

Smooth muscle IHC

Answer 8

Desmin

Question 8

Answer 8

Question 9

Answer 9

Question 9

Answer 9

ADIPOCYTIC TUMOR: FIBROLIPOMA

• Strands of collagenous, fibrous connective tissue within mature adipocytes

Question 9

Answer 9

Question 10

Answer 10

FIBROUS TUMOR: ANGIOFIBROMA

Question 10

Answer 10

FIBROUS TUMOR: HYPERTROPHIC SCAR

• Nodular, whorled masses
• More cellular than keloid
• Vertically aligned vessels

Question 11

Answer 11

FIBROUS TUMOR: HYPERTROPHIC SCAR

Question 12

Answer 12

Question 13

Answer 13

FIBROUS TUMOR: KELOID

Question 14

Answer 14

FIBROUS TUMOR: FIBROEPITHELIAL POLYP(ACROCHORDON)

• Epidermis: may be hyperplastic and papillomatous, surrounding core of fibrovascular tissue
• Loose fibrocollagenous stroma

Question 15

Answer 15

FIBROUS TUMOR: DERMATOFIBROMA (FIBROUS HISTIOCYTOMA)

• Hyperplastic epidermis with basal layer hyperpigmentation
• Rounding up of collagen bundles (collagen balls)
• Fibroblast-like spindle cells, histiocytes and blood vessels in varying proportions
• Factor XIIIa positive

Question 16

How can you differentiate dermatofibroma from DFSP?

Answer 16

Factor XIIIa (+), CD34 (-)

Question 17

Answer 17

FIBROUS TUMOR: DERMATOFIBROMA

Question 18

Answer 18

Question 19

Answer 19

FIBROUS TUMOR: DERMATOFIBROSARCOMA PROTUBERANS

Question 20

• What is the diagnosis?
• Associated syndrome?

Answer 20

• Plexiform neurofibroma
• NF Type I

Question 21

- What is the diagnosis? - IHC Stain?

Answer 21

Dermatofibroma Factor XIIIa

Question 22

* What is the diagnosis? * What is the area of highlighted cells called?

Answer 22

Schwannoma Antoni B

Question 23

Answer 23

Leiomyoma Masson's Trichrome stain

Question 24

Answer 24

Neurofibroma Mast cell

Question 25

Answer 25

ANGIOFIBROMA Seen in: -Tuberous sclerosis -Fibrous papule of the face -Pearly penile papules

Question 26

What kind of tumors are Hypertrophic scar and keloid?

Answer 26

Fibroblastic Tumors

Question 27

Answer 27

Keloid