Benign Hyperplasia

Question 1

More common

Mediastinum, abdominal cavity

90% hyaline vascular type

10% plasma cell

Answer 1

Castleman Disease - Localized

Question 2

Histology shows:

Interfollicular vascularity

Hyalinized vessels

Mantle cell lymphocytes show onion skinning

What disease is most likely?

Answer 2

Castleman Disease - Localized

Question 3

Immunophenotype of Rosai-Dorman Disease

Answer 3

S100+

CD68+

CD1a -

Question 4

Sinus histiocytosis with massive LAD

Answer 4

Rosai-Dorman Disease

Question 5

Marked follicular hyperplasia

Sinusoidal dilation by monocytoid B-cells

Answer 5

Toxoplasmosis FH

Question 6

Geographic follicles with germinal centers

Follicle lysis –> invaginating small lymphocytes in GCs

Answer 6

HIV-associated FH

Question 7

Histolgy reveals active penetration of one cell by another which remains intact

Answer 7

Emperipolesis of Rosai-Dorman Disease

Question 8

Small and large histiocytic aggregates within interfollicular areas and encroach upon GCs

Answer 8

Epithelioid granulomas of Toxoplasmosis FH

Question 9

Interfollicular areas show multinucleated cells = Warthin Finkeldey cells

Answer 9

HIV-associated FH

Question 10

Palisading histiocytes with central necrosis

Answer 10

Cat-Scratch Disease FH

Question 11

Primary –> HHV-8

Almost all Plasma cell type

Answer 11

Castleman Disease - Multicentric (IL-6 Syndrome)

Question 12

Which stain to detect Bartonella henselae?

Answer 12

Warthin-Starry stain