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Block 6 Exam 3 > Zhu Pharm > Flashcards

Zhu Pharm Flashcards

1
Q

Drug for MM in non-pregnant patients who’ve received 1+ previous tx

A

Lenalidomide

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2
Q

Indicated for cutaneous manifestations of erythema nodosum leprosum

A

Thalidomide

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3
Q

Drug used for immunotherapy

A

Rituximab

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4
Q

Chimeric monoclonal antibody targeting CD20

A

Rituximab

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5
Q

Drug for MM in non-pregnant patients who’ve previously tried 2+ tx

A

Pomalidomide

CONTRAINDICATED IN PREGNANCY

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6
Q

Cardiotoxicity due to Doxorubicin can be reduced by co-administration of ___?

A

Dexrazoxane

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7
Q

Blocks PDGF receptor-alpha

A

Imatinib

  • a tyrosine kinase inhibitor targeting BCR-ABL
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8
Q

Treatment of diffusue large B cell lymphoma

A

RCHOP

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9
Q

Which drug do we give patients with relapsed APL?

A

Arsenic trioxide

  • Targets PML of PML-RARA fusion protein
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10
Q

What are the components of RCHOP chemotherapy?

What is RCHOP used for?

A

Rituximab

Cyclophosphamide, Doxorubicin, Vincristine, Prednisone

Indications: Follicular Lymphoma & DLBL

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11
Q

What are the components of FCMR?

A

Fludarabine

Cyclophosphamide

Mitoxantrone

Rituximab

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12
Q

AE of Bleomycin

A

Pulmonary toxicity

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13
Q

Down-regulates cytokines

Increaseses NK cells, IL-2, INF-gamma

Anti-angiogenic

A

Thalidomide

  • CONTRAINDICATED IN PREGNANCY!
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14
Q

What are the components of the BR regimen

A

Bendamustine

Rituximab

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15
Q

Induces leukemic cell apoptosis

A

Arsenic Trioxide

  • Targets PML of PLM-RARA fusion product
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16
Q

Inhibits DNA polymerase

A

Cytarabine

17
Q

Inhibits tumor & bone stromal cell interactions

MM cell growth arrest & apoptosis

A

Thalidomide

CONTRAINDICATED IN PREGNANCY

18
Q

Tx for MM resistant to 2+ prior tx

A

Carfilzomib

19
Q

Induces leukemic cell differentiation

A

Tretinoin

  • targets RARA of PML-RARA fusion protein
20
Q

First line for ALL

A

Pegasparagase

21
Q

Inhibits AMP/GMP synthesis and de novo purine synthesis

A

6-Mercaptopurine

22
Q

Inhibits NF-kappa B activation

A

Bortezomib

23
Q

Incorporates into DNA only

A

Cytarabine

24
Q

Drug interaction with Allopurinol

What is Allopurinol usually given for?

A

6-mercaptopurine

Allopurinol used to prevent tumor lysis syndrome

25
Q

Drug given to pt with resistant CML

Intolerant to 2 previous tyrosine kinase inhibitors

A

Omacetaxine

  • protein synthesis inhibitor
26
Q

Incorporates into both DNA and RNA

A

6-Mercaptopurine

27
Q

AE of Doxorubicin

A

Cardiotoxicity

28
Q

Drug for relapsed mantle cell lymphoma, or progressed after 2 prior tx

A

Lenolidomide

CONTRAINDICATED IN PREGNANCY

29
Q

What is the RCVP Regimen?

A

Rituximab

Cyclophosphamide

Vincristine

Prednisone

30
Q

Tx for newly diagnosed MM

Combo with Dexamethasone

A

Thalidomide

31
Q

3 indications for Cytarabine

A

AML

ALL

CML

32
Q

MOA of asparaginase & others

A

Catalyze deamination of asparagine

Asparagine –> Aspartate (neoplastic cells can’t use this for protein synthesis)

33
Q

Proteasome inhibitor

Indicated for MM (and) Mantle Cell lymphoma resistant to 1+ previous tx

A

Bortezomib

34
Q

Maintenance of ALL remission

A

6-Mercaptopurine

35
Q

Treatment of follicular lymphoma:

  • Stages I & II –>
  • Stages III & IV asymptomatic –>
  • Stages III & IV symptomatic –>
A
  • Stages I & II –> Radiation
  • Stages III & IV ASx –> Watch-and-wait
  • Stages III & IV Sx –> Chemotherapy (RCHOP), immunotherapy
36
Q

Drug for CML without drug interaction risks

A

Omacetaxine

37
Q

Irreversible proteasome inhibitor

A

Carfilzomib

38
Q

What is the regimen for Hodgkin Lymphoma?

What are the components?

A

ABVD

  • Doxyrubicin
  • Bleomycin
  • Vinblastine
  • Dacarbazine
39
Q

What drug is indicated for:

CLL

Indolent NHLs

A

Fludarabine

Block 6 Exam 3 (5 decks)

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