Benign Prostatic Hyperplasia: Etiology, Pathophysiology, Epidemiology, and Natural History Flashcards Preview

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Flashcards in Benign Prostatic Hyperplasia: Etiology, Pathophysiology, Epidemiology, and Natural History Deck (21)
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1

 Sex accessory tissues include the :(4)

They are believed to play a major, but unknown, role in the reproductive process


 

Sex accessory tissues include the prostate gland, seminal vesicles, ampullae, and bulbourethral glands. They are believed to play a major, but unknown, role in the reproductive process

2

The wolffian ducts develop into the seminal vesicles, epididymis, vas deferens, ampulla, and ejaculatory duct; the developmental growth of this group of glands is stimulated by: ___
 

fetal testosterone

3

The prostate first appears and starts its development from the urogenital sinus during the __month of fetal growth, and development is directed primarily by __

 

 

third

DHT

4

for prostate development to proceed, __ receptor is required to be functional in the mesenchyme.

 

ANDROGEN

5

 α1A. Research work has demonstrated three subtypes of the α1 -adrenergic receptor (α1A, α1B, and α1D), of which the α1A receptor appears to be linked to ___
 

α1A is linked to contraction .

6

Testosterone is synthesized in the Leydig cells of the testes from ___ by a series of __ reactions; however, once testosterone is reduced by __into DHT or to estrogens by aromatase, the process is irreversible.

PREGNENOLONE

REVERSIBLE

5a-reductase

7

 Less than __ of the total testosterone in the plasma is derived from DHEA.

1%

8

The majority of testosterone bound to plasma protein is associated with __.

Sex hormone-binding globulin (SHBG).

9

___ ISOFORM is mutated in 5α-reductase deficiency and is the dominant isoform present in the prostate gland.

TYPE 2 ISOFORM

10

The source of fructose in human seminal plasma is the ___

SEMINAL VESICLES

 

11

 The __ the length, the more actively the androgen receptor is thought to function.

SHORTER the POLY CAG repeats

12

 2. There are two major cellular components in the prostate:

 

epithelial and stromal.

13

 6. Because of the diurnal variation of serum testosterone, to avoid inconsistency it should be ___
 

measured in the morning.

14

the plasma half-life of testosterone is

 

10 to 20 minutes,

15

11. The source of prostaglandins, fructose, and semenogelin, and contribution of most volume to seminal fluid is the ___

 

SEMINAL VESICLES

16

he source of citrate, zinc, spermine, and choline is:

the prostate

17

__ is a serine protease and degrades semenogelin.

Semenogelin gives rise to the __ of semen.

 

 

PSA

COAGULATION

18

6. Increases in human kallikrein 2, pro-PSA, and bound PSA are associated with __ cancer.

 

 

prostate ca

19

{___ produced in the prostate may be elevated in prostate cancer; it is also produced in the bone and may be elevated in diseases that affect the bone such as Paget disease, osteoporosis, and bone metastases.
 

 Acid phosphatase

20

The ____ develop into the seminal vesicles, epididymis, vas deferens, ampulla, and ejaculatory duct; the developmental growth of this group of glands is stimulated by fetal testosterone and not DHT.

WOLFFIAN DUCTS

21