Benzodiazepines 2 Flashcards Preview

19 Sedative, hypnotic, anxiolytic drugs > Benzodiazepines 2 > Flashcards

Flashcards in Benzodiazepines 2 Deck (18)
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1

Alprazolam - clinical uses

Anxiety, panic disorder

2

Benzodiazepines used for anxiety disorders

Alprazolam
Chlordiazepoxide
Clonazepam
Diazepam
Lorazepam
Oxazepam

3

Benzodiazepines used for insomnia

Estazolam
Flurazepam
Temazepam
Triazolam

4

Benzodiazepines used for alcohol detoxification

Chlordiazepoxide
Diazepam

5

Chlordiazepoxide - indications

Alcohol detoxification, anxiety

6

Benzodiazepines used in seizure disorders

Clonazepam
Diazepam
Lorazepam

7

Clonazepam - indications

Anixiety, panic disorder.
Seizure disorders

8

Diazepam - indications

Alcohol detoxification, anxiety, muscle spasms, seizure disorders spasticity. Terminate recurrent seizures

9

Lorazepam - indications

Anxiety, seizure disorders

10

Midazolam - indications

Anesthesia for e.g. endoscopy, minor surgery

11

Oxazepam - indications

Anxiety

12

Benzodiazepines - adverse effects

Abrupt withdrawal: seizures. Arrhythmia, CNS depression, drug dependence, hypotension, mild respiratory depression

13

Which benzodiazepines are more likely to cause drug hangover?

Chlordiazepoxide
Diazepam
Flurazepam

14

Estazolam, flurazepam, tamazepam and triazolam - adverse effects

Hypersensitivity (anaphylaxis, angioedema), complex sleep-related behaviors (driving, phone calls, sex, making/eating food)

15

Which benzodiazepine is less and which is more likely to cause rebound insomnia?

Least likely: Flurazepam
Most likely: Triazolam

16

Bezodiazepines - interactions

All: Alcohol and other CNS depressants - potentiated effect.
Most: Cimetidine increases and rifampin decreases serum levels

17

Benzodiazepines with interactions differing from the rest

Alprazolam: Fluoxetine & fluvoxamine - increase serum levels.
Midazolam: CCB, erythromycin, ketoconazole increase serum levels.
Triazolam: Cimetidine, erythromycin, ketoconazole and oral contraceptives increase serum levels.

18

Which benzodiazepines interact with cimetidine and rifampin?

Interact with both: Chlordiazepoxide, clonazepam, diazepam, estazolam, flurazepam, temazepam.
Interact with rifampin: Lorazepam, oxazepam.